{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T21:13:09Z","timestamp":1782681189334,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic asthma is an important respiratory system problem characterized by airway inflammation, breathlessness, and bronchoconstriction. Allergic asthma and its outcomes are triggered by type 2 allergic immune responses. Tectorigenin is a methoxy\u2010isoflavone with anti\u2010inflammatory effects. In this study, we investigated the effects of tectorigenin on the pathophysiology of allergic asthma in an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Asthmatic mice were treated with tectorigenin. Then airway hyperresponsiveness (AHR), eosinophil percentage, levels of interleukin (IL)\u201033, IL\u201025, IL\u201013, IL\u20105, IL\u20104, total and ovalbumin (OVA)\u2010specific immunoglobulin (Ig)E, and lung histopathology were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Tectorigenin significantly (P \u2329 0.05) reduced eosinophil infiltration (41\u2009\u00b1\u20097%) in the broncho\u2010alveolar lavage fluid (BALF), serum IL\u20105 level (41\u2009\u00b1\u20095, pg\/mL), and bronchial and vascular inflammation (scores of 1.3\u2009\u00b1\u20090.2 and 1.1\u2009\u00b1\u20090.3, respectively) but had no significant effects on AHR, serum levels of IL\u201033, \u221225, \u221213, and \u22124 (403\u2009\u00b1\u200924, 56\u2009\u00b1\u20097, 154\u2009\u00b1\u200911, and 89\u2009\u00b1\u20096 pg\/mL, respectively), total and OVA\u2010specific IgE (2684\u2009\u00b1\u2009265 and 264\u2009\u00b1\u200919\u2009ng\/mL, respectively), goblet cell hyperplasia, and mucus production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tectorigenin could control inflammation and the secretion of inflammatory mediators of asthma, so it can be regarded as a potential antiasthma treatment with the ability to control eosinophilia\u2010related problems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13742","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T02:23:56Z","timestamp":1714098236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Studying of anti\u2010inflammatory and antioxidant effects of tectorigenin in ovalbumin\u2010induced asthma mice models"],"prefix":"10.1111","volume":"18","author":[{"given":"Jingning","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional Medicine and Western Medicine Xi'an Children's Hospital  Xi'an 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