{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:33Z","timestamp":1787014053809,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371837"],"award-info":[{"award-number":["82371837"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In order to improve survival outcomes in resectable non\u2010small cell lung cancer (NSCLC), strategies for neoadjuvant therapy need to be revisited. We evaluated and compared the efficacy of different neoadjuvant therapeutic modalities in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 258 patients with clinical stage IIA to IIIB NSCLC was included. All the patients underwent surgical resection after one to four cycles of neoadjuvant treatment consisting of chemotherapy (83), immunotherapy (23), and immunotherapy plus chemotherapy (152).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The radiologic response rate in the combined immunochemotherapy group was 67.8%, higher than that of 48.2% in the chemotherapy group and 4.3% in the immunotherapy group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). An improved major pathological response (MPR) was also achieved in the combined therapy group compared with the chemotherapy group and the immunotherapy group (53.9% vs. 10.8% vs. 8.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients in the combined therapy group had a significant trend toward longer disease\u2010free survival than those in the chemotherapy alone group (3\u2010year disease\u2010free survival [DFS] of 68.79% vs. 50.81%; hazard ratio [HR] for progression or death, 0.477;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Multivariate Cox analysis identified radical surgery (HR, 0.328;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), ypN0\u20131 stage (HR, 0.591;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038) and MPR result (HR, 0.362;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) to be independent prognostic factors for DFS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neoadjuvant treatment with a combination of immunotherapy plus chemotherapy appears to achieve higher radiological and pathological responses than monotherapy for IIA\u2010IIIB NSCLC. Log\u2010rank analysis showed that a better outcome could be expected in patients with the addition of immunotherapy to neoadjuvant chemotherapy if compared with patients with chemotherapy alone in terms of DFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.13761","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T01:44:20Z","timestamp":1714614260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical outcomes associated with neoadjuvant therapy for the treatment of resectable non\u2010small cell lung cancer in real\u2010world practice"],"prefix":"10.1111","volume":"18","author":[{"given":"Xiaojie","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University, School of Medicine  Hangzhou 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Affiliated Hospital of Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6659-4824","authenticated-orcid":false,"given":"Zijian","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Quzhou People's Hospital  Quzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University, School of Medicine  Hangzhou 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