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Three databases (MEDline, Scopus, and Web of Science) were searched using the following keywords: pulmonary surfactant, surface\u2010active agents, exogenous surfactant, pulmonary contusion, and lung contusion for articles published between 1945 and February 2023, with no language restrictions. Four reviewers independently rated the studies for inclusion, and the other four reviewers resolved conflicts. Of the 100 articles screened, six articles were included in the review. Owing to the limited number of papers on this topic, various types of studies were included (two clinical studies, two experiments, and two case reports). In all the studies, surfactant administration improved the selected ventilation parameters. The most frequently used type of surfactant was Curosurf\u00ae in the concentration of 25\u2009mg\/kg of ideal body weight. In most studies, the administration of a surfactant by bronchoscopy into the segmental bronchi was the preferable way of administration. In both clinical studies, patients who received surfactants required shorter ventilation times. The administration of exogenous surfactants improved ventilatory parameters and, thus, reduced the need for less aggressive artificial lung ventilation and ventilation days. The animal\u2010derived surfactant Curosurf\u00ae seems to be the most suitable substance; however, the ideal concentration remains unclear. The ideal route of administration involves a bronchoscope in the segmental bronchi.<\/jats:p>","DOI":"10.1111\/crj.13776","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:30:09Z","timestamp":1716445809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exogenous surfactant for lung contusion causing ARDS: A systematic review of clinical and experimental reports"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4160-0022","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Merkl","sequence":"first","affiliation":[{"name":"Military Faculty of Medicine, Department of Military Surgery University of Defence  Hradec Kralove Czech Republic"},{"name":"Department of Pediatric Surgery and Traumatology, University Hospital Hradec Kralove, Faculty of Medicine Hradec Kralove Charles University  Prague Czech Republic"},{"name":"Faculty of Medicine in Hradec Kralove Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Astapenko","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Resuscitation and Intensive Medicine, University Hospital Hradec Kralove, Faculty of Medicine Hradec Kralove Charles University  Prague Czech Republic"},{"name":"Faculty of Health Studies Technical University in Liberec  Liberec Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek","family":"\u0160tichhauer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Traumatology, University Hospital Hradec Kralove, Faculty of Medicine Hradec Kralove Charles University  Prague Czech Republic"},{"name":"Faculty of Medicine in Hradec Kralove Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton\u00edn","family":"\u0160afus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Traumatology, University Hospital Hradec Kralove, Faculty of Medicine Hradec Kralove Charles University  Prague Czech Republic"},{"name":"Faculty of Medicine in Hradec Kralove Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Du\u0161ek","sequence":"additional","affiliation":[{"name":"Military Faculty of Medicine, Department of Military Surgery University of Defence  Hradec Kralove Czech Republic"},{"name":"Faculty of Medicine in Hradec Kralove Charles University  Prague Czech Republic"},{"name":"Department of Surgery, University Hospital Hradec Kralove, Faculty of Medicine Hradec Kralove Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Kotek","sequence":"additional","affiliation":[{"name":"Military Faculty of Medicine, Department of Military Surgery University of Defence  Hradec Kralove Czech Republic"},{"name":"Department of Surgery, University Hospital Hradec Kralove, Faculty of Medicine Hradec Kralove Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"\u0158eh\u00e1k","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in Hradec Kralove Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Lochman","sequence":"additional","affiliation":[{"name":"Military Faculty of Medicine, Department of Military Surgery University of Defence  Hradec Kralove Czech Republic"},{"name":"Faculty of Medicine in Hradec Kralove Charles University  Prague Czech Republic"},{"name":"Department of Surgery, University Hospital Hradec Kralove, Faculty of Medicine Hradec Kralove Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_12_2_1","series-title":"Chinese Journal of Traumatology \u2013 English Edition","first-page":"125","volume-title":"Blunt Trauma Related Chest Wall and Pulmonary Injuries: An Overview","author":"Dogrul BN","year":"2020"},{"key":"e_1_2_12_3_1","first-page":"7","article-title":"Lung contusion: a clinico\u2010pathological entity with unpredictable clinical course","volume":"1","author":"Ahmad Ganie F","year":"2013","journal-title":"Bull. 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