{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:05:04Z","timestamp":1791223504932,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Lung squamous cell carcinoma (LUSC) is characterized by a high rate of metastasis and recurrence, leading to a poor prognosis for affected patients. Intestinal metastasis of LUSC is a rare clinical occurrence. Treatment options for LUSC patients with intestinal metastasis are limited, and no standard therapy guidelines exist for managing these cases. In this review, we discuss the clinical features, diagnosis, and treatment of LUSC patients with intestinal metastasis and present a rare case of LUSC with intestinal metastasis. We describe a patient who presented with a severe cough and chest pain and diagnosed with LUSC and bone tumor. Initially, the primary LUSC and bone tumor were controlled with standard treatments. However, the primary LUSC reoccurred shortly after treatment, this time with intestinal metastasis, for which effective treatments are lacking. Our observation from the case suggests that LUSC metastasizing to intestinal tract is associated with a poorer prognosis.<\/jats:p>","DOI":"10.1111\/crj.13817","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T05:09:47Z","timestamp":1723180187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Primary Lung Squamous Cell Carcinoma With Intestinal Metastasis: A Case Report and Literature Review"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2878-3496","authenticated-orcid":false,"given":"Jin","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiewei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikun","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8136-7442","authenticated-orcid":false,"given":"Hu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3775"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2169-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870415)59:8<1486::AID-CNCR2820590815>3.0.CO;2-W"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02256525"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02586842"},{"key":"e_1_2_9_8_1","first-page":"358","article-title":"Metastasis to the Colon From Primary Bronchogenic Carcinoma Presenting as Occult Gastrointestinal Bleeding\u2010\u2010Report of a Case","volume":"26","author":"Wegener M.","year":"1988","journal-title":"Zeitschrift f\u00fcr Gastroenterologie"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)00646-7"},{"key":"e_1_2_9_10_1","first-page":"199","article-title":"Colonic Metastasis From Bronchogenic Carcinoma Presenting as Pancolitis","volume":"48","author":"John A. 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