{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:54:39Z","timestamp":1788188079848,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK065988"],"award-info":[{"award-number":["P30 DK065988"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Elexacaftor\/tezacaftor\/ivacaftor (E\/T\/I) has provided life\u2010changing pharmacotherapy for many people with cystic fibrosis (CF), but conflicting literature exists regarding the effect on mental health. While some reports suggest E\/T\/I may induce adverse psychiatric symptoms, others report improvements in mental health symptoms. To add to this growing body of knowledge, we retrospectively analyzed depression and anxiety symptoms before and after E\/T\/I initiation in adults with CF at a single large US CF center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patient Health Questionnaire\u20109 (PHQ\u20109) and Generalized Anxiety Disorder\u20107 (GAD\u20107) scores recorded in a database were studied. Patients with scores collected before and after E\/T\/I initiation were included. Regression analyses described associations between score changes and age, race, ethnicity, sex, CFTR variant, and prior depression and\/or anxiety diagnoses. Secondary analyses examined possible confounding effects of the COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no change in mean GAD\u20107 (0.5\u2009\u00b1\u20095.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.41) or PHQ\u20109 (\u22120.02\u2009\u00b1\u20096.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.97) scores following initiation of E\/T\/I (<jats:italic>N<\/jats:italic>\u2009=\u200986). A trend between a prior diagnosis of depression and worsening in PHQ\u20109 post\u2010E\/T\/I was observed (OR 3.58; <jats:italic>p<\/jats:italic>\u2009=\u20090.054).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with E\/T\/I does not lead to changes in depression or anxiety symptoms at the population level in this single center cohort study. A prior diagnosis of depression trended towards an increased odds of worsening PHQ\u20109 scores after E\/T\/I initiation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.70007","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T06:20:06Z","timestamp":1724998806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of Depression and Anxiety Scores Following Initiation of Elexacaftor\/Tezacaftor\/Ivacaftor in Adults With Cystic Fibrosis"],"prefix":"10.1111","volume":"18","author":[{"given":"Harish","family":"Pudukodu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margret\u00a0Z.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Baylor University  Waco Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Ceppe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine University of North Carolina\u2010Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott\u00a0H.","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine University of North Carolina\u2010Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-5076","authenticated-orcid":false,"given":"Jennifer\u00a0L.","family":"Goralski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine University of North Carolina\u2010Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-4005","authenticated-orcid":false,"given":"Nathaniel\u00a0A.","family":"Sowa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of North Carolina\u2010Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573406412666160608113235"},{"key":"e_1_2_10_3_1","volume-title":"GeneReviews(\u00ae)","author":"Moskowitz S. 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