{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:40:48Z","timestamp":1768560048015,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report a case of 59\u2010year\u2010old female with solitary bilateral renal metastases after surgery of stage IA primary lung adenocarcinoma who underwent next\u2010generation sequencing (NGS) of both lesions. The patient received right upper lobectomy and lymph node dissection, which revealed primary invasive lung adenocarcinoma (pT1cN0M0, stage IA3). Two years following this, positron emission tomography\u2013computed tomography (PET\/CT) revealed multiple masses in both kidneys without other distant metastases, and ultrasonography\u2010guided puncture biopsy indicated the presence of metastatic lung adenocarcinoma. The NGS of both the primary and metastatic lesions revealed the co\u2010alteration of epidermal growth factor receptor (<jats:italic>EGFR<\/jats:italic>), RB transcriptional corepressor 1 (<jats:italic>RB1<\/jats:italic>), and mitogen\u2010activated protein kinase kinase 1 (<jats:italic>MAP3K1<\/jats:italic>), which is potentially associated with the risk of renal metastasis in early postoperative non\u2010small cell lung cancer.<\/jats:p>","DOI":"10.1111\/crj.70018","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T13:51:28Z","timestamp":1728568288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Solitary Renal Metastases From Stage IA Primary Lung Adenocarcinoma With Co\u2010Alteration of <i>EGFR<\/i>, <i>RB1<\/i>, and <i>MAP3K1<\/i>: A Case Report"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2557-4761","authenticated-orcid":false,"given":"Zhu","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Zhenzhen","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xie","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Guangxi Academy of Medical Sciences &amp; the People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6012-7500","authenticated-orcid":false,"given":"Li","family":"Shuben","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2014.410"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/357481"},{"issue":"6","key":"e_1_2_9_4_1","article-title":"Isolated Renal Metastasis From Primary Lung Squamous Cell Carcinoma With Synchronous Small Cell Lung Cancer","volume":"11","author":"Numan L.","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.632221"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.110825"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160509100120"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2022.01.134"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014310"},{"issue":"7","key":"e_1_2_9_10_1","first-page":"489","article-title":"Renal Metastasis Originating From Pulmonary Carcinoma: A Case Report","volume":"47","author":"Uemura M.","year":"2001","journal-title":"Hinyokika Kiyo"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197907000-00013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-023-01627-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2015.11929235"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx123.263"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.05.099"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.03.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0698-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyac094"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14664"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.06.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01585"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209507"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313206"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-023-00805-w"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2204.0023"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2023.06.004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102205"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T03:57:04Z","timestamp":1729742224000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.70018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/crj.70018"],"URL":"https:\/\/doi.org\/10.1111\/crj.70018","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70018"}}