{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:04:48Z","timestamp":1790643888848,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bronchiectasis exacerbation (BE) is associated with unfavorable sequelae in other organs such as the cardiovascular system; data regarding its impact on adverse term renal outcomes, however, is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A territory\u2010wide retrospective cohort study was conducted in Hong Kong between 1\/1\/1993 and 31\/12\/2017. All patients with bronchiectasis followed in the public healthcare system in 2017 were classified as \u201cExacerbators\u201d or \u201cNon\u2010Exacerbators,\u201d and their adverse renal outcomes (renal progression [decrease in eGFR by 30\u2009mL\/min lasted for more than 12\u2009months during follow up], acute kidney injury [AKI], and annual rate of eGFR decline) in the ensuing 7\u2009years were compared. Results were also analyzed in the 1:1 propensity score matched (PSM) cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7929 patients (1074 \u201cExacerbators\u201d group and 6855 \u201cNon\u2010exacerbators\u201d) were followed for 6.2\u2009\u00b1\u20091.6\u2009years. A total of 1570 patients (19.8%) had renal progression, and 935 (11.8%) patients developed AKI. \u201cExacerbators\u201d showed significantly increased risk of renal progression (adjusted odds ratio [aOR] 1. 27 [95% CI 1.08\u20131.50, <jats:italic>p<\/jats:italic>\u2009=\u20090.003]), more rapid eGFR decline (\u22123.67 [\u22121.74 to \u22126.54] vs. \u22123.03 [\u22121.56 to \u22125.12] mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>\/year, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) and AKI (aOR 1.99; 95% CI 1.44\u20132.73, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) than the \u201cNon\u2010exacerbators.\u201d Annual number of BE was associated with renal progression (aOR 1.45; 95% CI 1.22\u20131.72, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and AKI (aOR 2.00; 95% CI 1.38\u20132.91, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Results were consistent in the analysis with the PSM cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Renal progression and AKI are common among patients with bronchiectasis, and BE is an independent risk factor for adverse renal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.70029","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T11:11:27Z","timestamp":1736593887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bronchiectasis Exacerbation Increases the Risk of Adverse Renal Outcomes\u2014Results From a Large Territory\u2010Wide Cohort Study"],"prefix":"10.1111","volume":"19","author":[{"given":"Wang\u00a0Chun","family":"Kwok","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine and Critical Care Medicine, Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pok Fu Lam Hong Kong SAR 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