{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:28:14Z","timestamp":1753878494899,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The provision of treatment for epidermal growth factor receptor (EGFR)\u2010mutated nonsmall cell lung cancer (NSCLC) patients has increased in Korea. However, multicenter studies on the clinicopathologic dataset and treatment outcomes, using a large\u2010scale dataset, have not been conducted. The current study is a prospective and retrospective multicenter observational cohort study that registers all stages of EGFR\u2010mutated NSCLC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Korean EGFR Registry was designed to enroll 2000 patients with all stages of EGFR\u2010mutated NSCLC from 40 university hospitals across Korea. This study, encompassing both retrospective and prospective cohorts, aims to analyze clinical characteristics, treatment modalities, and outcomes in these patients. Data collection will include patient demographics, smoking history, quality of life assessments, pathological data, and treatment outcomes, with follow\u2010up until December 2026. The primary endpoint is disease\u2010free survival in patients who have undergone radical therapy (surgery and radiotherapy) or progression\u2010free survival in those receiving targeted therapy (first, second, and subsequent lines), chemotherapy (first and subsequent lines), combination therapy, and palliative\/maintenance therapy according to stages of EGFR\u2010mutated NSCLC. The study will explore the diagnostic methods for EGFR mutations, clinical outcomes based on treatment modalities, and metastatic patterns in EGFR\u2010mutated NSCLC patients. Moreover, it will investigate various aspects, including the safety and efficacy of a new third\u2010generation EGFR tyrosine kinase inhibitor (TKI), lazertinib, approved for both first\u2010 and second\u2010line treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study is expected to provide valuable insights into the epidemiology, risk factors, progression, and treatment outcomes of EGFR\u2010mutated NSCLC in Korea. The Korean EGFR Registry will contribute significantly to the understanding of the complex dynamics of EGFR\u2010mutated NSCLC, aiding in the development of more effective and personalized treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.70043","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T04:40:37Z","timestamp":1736138437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation"],"prefix":"10.1111","volume":"19","author":[{"given":"Chang\u00a0Dong","family":"Yeo","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine Catholic University of Korea  Seoul Republic of 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-2748","authenticated-orcid":false,"given":"Jeong\u00a0Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine, College of Medicine Chungnam National University  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u00a0Yup","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University School of Medicine  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of 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