{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:52:14Z","timestamp":1790355134789,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472184"],"award-info":[{"award-number":["82472184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2021YFC2501800"],"award-info":[{"award-number":["2021YFC2501800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In recent times, the applications of continuous renal replacement therapy (CRRT) beyond kidney\u2010related conditions have been progressively increasing, and its implementation in randomized controlled trials (RCTs) specifically for acute respiratory distress syndrome (ARDS) has been documented. This meta\u2010analysis compiles all existing RCTs to assess whether CRRT benefits ARDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched 12 databases in English and Chinese and two clinical trial centers up to November 28, 2023. The main outcome indicator is the mortality rate. Secondary outcome indicators include incidence of ventilator\u2010associated pneumonia (VAP), ICU length of stay, mechanical ventilation time, oxygenation index (OI) at 24\u2009h (h), OI at 48\u2009h, OI at 72\u2009h, OI at 7\u2009days (d), partial pressure of oxygen (PaO<jats:sub>2<\/jats:sub>) at 72\u2009h, Acute Physiology and Chronic Health Evaluation II (APACHE II) score at 24\u2009h, APACHE II score at 48\u2009h, APACHE II score at 72\u2009h, APACHE II score at 7\u2009d, extravascular lung water indexes (EVLWI) at 72\u2009h, TNF\u2010\u03b1 at 24\u2009h, TNF\u2010\u03b1 at 7\u2009d, IL\u20106 at 24\u2009h, IL\u20106 at 48\u2009h, IL\u20106 at 72\u2009h, and IL\u20106 at 7\u2009d. Statistical measures utilized include risk ratios (RR), weighted mean difference (WMD), and 95% confidence intervals (95% CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We summarized 36 studies, including 2123 patients. It was found that for ARDS, using CRRT in addition to conventional therapy can reduce the mortality rate (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%; RR: 0.40; 95% CI: 0.30\u20130.53; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), the incidence of VAP (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%; RR: 0.44; 95% CI: 0.33\u20130.59; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), ICU length of stay, mechanical ventilation time, and EVLWI at 72\u2009h, as well as APACHE II score, TNF\u2010\u03b1, and IL\u20106 at various time points. Additionally, it can increase OI during different time intervals and PaO<jats:sub>2<\/jats:sub> at 72\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010quality evidence suggests that compared with conventional therapy alone, the use of CRRT may be associated with a lower mortality rate, the incidence of VAP, ICU length of stay, mechanical ventilation time, EVLWI, APACHE II score, TNF\u2010\u03b1, and IL\u20106 and may be related to better respiratory function. CRRT may be beneficial for ARDS patients. Future multicenter, well\u2010designed, high\u2010quality RCTs are needed to substantiate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.70045","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:08:27Z","timestamp":1735880907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["New Insights on Continuous Renal Replacement Therapy for Acute Respiratory Distress Syndrome: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Siyao","family":"Zeng","sequence":"first","affiliation":[{"name":"Graduate School Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanpeng","family":"Cui","sequence":"additional","affiliation":[{"name":"Graduate School Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghe","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-0072","authenticated-orcid":false,"given":"Hongliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00439\u20106"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)00578\u2010X"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.12.019"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01439\u20108"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003571"},{"key":"e_1_2_13_8_1","first-page":"730","article-title":"Acute Respiratory Distress Syndrome: Diagnosis and Management","volume":"101","author":"Saguil A.","year":"2020","journal-title":"American Family Physician"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366\u20106999.20141869"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0116\u20102016"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2022.05.002"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S164628"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5301\/IJAO.2011.7742"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000379"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm\u201021\u20102168"},{"key":"e_1_2_13_16_1","first-page":"2523","article-title":"Efficacy of Continuous Renal Replacement Therapy in the Treatment of Severe Acute Pancreatitis Associated Acute Respiratory Distress Syndrome","volume":"18","author":"Cui H. 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