{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:40:54Z","timestamp":1769730054569,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This expanded access program (EAP) provided ruxolitinib (oral, selective Janus kinase [JAK]1\/JAK2 inhibitor) for emergency treatment of COVID\u201019\u2013associated cytokine storm in patients eligible for hospitalization (NCT04355793).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients received ruxolitinib 5\u2009mg twice daily (preferred regimen when tolerated) or once daily for \u2264\u200914\u2009days, or until determination of no clinical benefit was made. Outcomes were clinical status, physician\u2010assessed clinical benefit, and serious adverse event (SAE) incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 312 patients, 45.5% achieved \u2265\u20091\u2010point clinical status improvement. Physician\u2010assessed clinical benefit was reported in 42.6% of evaluable patients. SAEs occurred in 42.9%, with 2.6% experiencing an SAE suspected to be ruxolitinib related.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, some hospitalized patients with COVID\u201019\u2013associated cytokine storm who received ruxolitinib experienced clinical status improvement; ruxolitinib was well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> identifier: NCT04355793<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.70050","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:16:23Z","timestamp":1744118183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ruxolitinib for Emergency Treatment of COVID\u201019\u2013Associated Cytokine Storm: Findings From an 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