{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:39Z","timestamp":1792788639885,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mechanical ventilation is a significant risk factor for developing ventilator\u2010associated pneumonia. Although silver\u2010coated endotracheal tubes have been shown to reduce the bacterial burden, the efficacy of silver\u2010based ion additive ventilator circuits in reducing bacterial colonization remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010site, randomized controlled trial compared the incidence of bacterial contamination between a silver\u2010additive ventilator circuit and a ventilator circuit that did not have a silver additive. Bacterial samples were collected from the inspiratory limb and Y\u2010adaptor of the circuit and analyzed using culture and identification methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bacterial growth was observed in all samples from the control group and in 93.7% and 81.2% of inspiratory limb and Y\u2010adaptor samples, respectively, from the study group. The colony counts in the inspiratory limb samples were significantly different between the groups, with a higher proportion of undesirable colony counts in the control group compared with the study group. No significant difference between the groups was observed in the colony counts in the Y\u2010adaptor samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of a silver\u2010additive ventilator circuit may reduce bacterial circuit colonization. However, further research with larger sample sizes and more diverse patient populations is necessary to confirm these findings.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrial.gov\">ClinicalTrial.gov<\/jats:ext-link>: NCT04927806<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.70058","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:03:46Z","timestamp":1741741426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bacterial Colonization of Silver\u2010Additive Ventilator Circuit in Patients Receiving Mechanical Ventilation: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5143-6873","authenticated-orcid":false,"given":"Ke\u2010Yun","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Respiratory Therapy, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Cardiovascular and Pulmonary Rehabilitation Center, Fu Jen Catholic University Hospital Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Telehealth Center Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Artificial Intelligence Development Center Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8593-8492","authenticated-orcid":false,"given":"Wei\u2010Lun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Department of Critical Care Medicine, Fu Jen Catholic University Hospital Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1812-3857","authenticated-orcid":false,"given":"Chao\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Therapy, Fu Jen Catholic University Hospital Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Department of Life Science Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9453-5772","authenticated-orcid":false,"given":"Chia\u2010Hui","family":"Su","sequence":"additional","affiliation":[{"name":"Infection Control Center, Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1900-5229","authenticated-orcid":false,"given":"Shih\u2010Hsing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Therapy, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Department of Respiratory Therapy, Fu Jen Catholic University Hospital Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4579-7947","authenticated-orcid":false,"given":"Yu\u2010Tzu","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","first-page":"774","article-title":"The Ventilator Circuit and Ventilator\u2010Associated Pneumonia","volume":"50","author":"Branson R. 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