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Artificial intelligence (AI) has been applied in diagnosis of cancers. We used the AI\u2010assisted lung nodule diagnostic system in the screening of lung nodules and lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 66\u2010year\u2010old male complained of coughs and nodules in the right lung of 3\u2010year duration. A ground\u2010glass opacity was found in the right upper lung by routine computed tomography (CT). He had no family history of cancer, genetic diseases, or infectious diseases. AI\u2010assisted analysis found four nodules, of which one was with the risk of malignancy of 88% (LungRads3), one was with the risk of malignancy of 15% (LungRads2), and the other two were smaller in size and considered benign. The patient underwent a thoracoscopic wedge resection of the right upper lung. The intraoperative frozen section pathology report confirmed invasive pulmonary adenocarcinoma, grade II, and primarily of alveolar and adherent types without metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, AI\u2010assisted lung nodule diagnostic system is effective in the screening of lung nodules and the differentiation between benign and malignant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.70073","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T08:10:03Z","timestamp":1748419803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Application of Artificial Intelligence\u2010Assisted Analysis of Invasive Pulmonary Adenocarcinoma Less Than 6\u2009mm in Size: A Case Report and Literature Review"],"prefix":"10.1111","volume":"19","author":[{"given":"Lu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Guizhou Provincial People's Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-143X","authenticated-orcid":false,"given":"Dawei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Fudan University Affiliated Zhongshan Hospital  Shanghai China"},{"name":"Shanghai Respiratory Internet of Things Medical Engineering Technology Research Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Guizhou Provincial People's Hospital  Guiyang 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