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The patient presented with an anterior mediastinal mass that invaded the left brachiocephalic trunk vein, resulting in the formation of a carcinoma thrombus in the right atrium, superior vena cava, left brachiocephalic trunk vein, and left internal jugular vein (Masaoka stage IV). No indication for surgery was assessed by surgical consultation. After six cycles of chemotherapy and chest radiotherapy, the tumor size decreased from 72.43 to 24\u2009mm, showing a significant improvement in patient efficacy. After a follow\u2010up of 50\u2009months, the patient remained well, without local recurrence or distal metastasis, and maintained a partial response (PR).<\/jats:p>","DOI":"10.1111\/crj.70081","type":"journal-article","created":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T22:43:45Z","timestamp":1750632225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient With Advanced Aggressive B2 Thymoma Achieved Positive Outcomes Post CAP\u2010Endostar Combination Therapy"],"prefix":"10.1111","volume":"19","author":[{"given":"Min","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9722-5746","authenticated-orcid":false,"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13053"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000663"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.11.161"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13319"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.08.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2007.05.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12891"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.9607"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.08.034"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.70081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T07:43:33Z","timestamp":1750837413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.70081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/crj.70081"],"URL":"https:\/\/doi.org\/10.1111\/crj.70081","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"type":"print","value":"1752-6981"},{"type":"electronic","value":"1752-699X"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70081"}}