{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:51:57Z","timestamp":1765889517082,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fractional exhaled nitric oxide (FE<jats:sub>NO<\/jats:sub>) serves as a marker of eosinophil\u2010mediated airway inflammation and has been used in asthma diagnosis, phenotyping, and guidance regarding selection and adjustment of asthma therapy. Studies suggested that FE<jats:sub>NO<\/jats:sub> correlated with asthma symptoms, peripheral blood eosinophil level, blood IgE level, and spirometry indicators of airway obstruction. However, the results are inconsistent across studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cross\u2010sectional study was conducted in Queen Mary Hospital among adult patients with severe asthma. Patients had spirometry with bronchodilator reversibility and same\u2010day FE<jats:sub>NO<\/jats:sub>. Asthma control test (ACT) score and blood eosinophil and total IgE levels were measured within 4\u2009weeks of FE<jats:sub>NO<\/jats:sub> and spirometry. The primary outcome was the correlation of FE<jats:sub>NO<\/jats:sub> and spirometric values. The secondary outcomes included the correlation of FE<jats:sub>NO<\/jats:sub> with ACT score, blood eosinophil, and total IgE levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010five severe asthma patients with FE<jats:sub>NO<\/jats:sub> performed were included in the study. FE<jats:sub>NO<\/jats:sub> was negatively correlated with pre\u2010bronchodilator FEV<jats:sub>1<\/jats:sub> (L) (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.188, <jats:italic>p<\/jats:italic>\u2009=\u20090.029), pre\u2010bronchodilator FEV<jats:sub>1<\/jats:sub> (% predicted) (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.169, <jats:italic>p<\/jats:italic>\u2009=\u20090.050), pre\u2010bronchodilator FEV1\/FVC ratio (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.269, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), and post\u2010bronchodilator FEV<jats:sub>1<\/jats:sub>\/FVC (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.215, <jats:italic>p<\/jats:italic>\u2009=\u20090.018). FE<jats:sub>NO<\/jats:sub> was positively correlated with bronchodilator reversibility (mL) (<jats:italic>r<\/jats:italic>\u2009=\u20090.248, <jats:italic>p<\/jats:italic>\u2009=\u20090.006) and bronchodilator reversibility (%) (<jats:italic>r<\/jats:italic>\u2009=\u20090.823, <jats:italic>p<\/jats:italic>\u2009=\u20090.002)<jats:italic>,<\/jats:italic> baseline blood eosinophil level by absolute cell count (<jats:italic>r<\/jats:italic>\u2009=\u20090.308, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and by percentage (<jats:italic>r<\/jats:italic>\u2009=\u20090.361, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In adult patients with severe asthma, FE<jats:sub>NO<\/jats:sub> might have a negative correlation with the FEV<jats:sub>1<\/jats:sub>, FEV<jats:sub>1<\/jats:sub>\/FVC ratio, and a positive correlation with bronchodilator reversibility, as well as with blood eosinophil levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.70094","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T07:53:59Z","timestamp":1753343639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation of FE<sub>NO<\/sub> With Spirometric Measurements and Blood Eosinophil Level in Patients With Severe Asthma"],"prefix":"10.1111","volume":"19","author":[{"given":"Wang\u00a0Chun","family":"Kwok","sequence":"first","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pokfulam Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary\u00a0Sau\u00a0Man","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pokfulam Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence\u00a0Chi\u00a0Chun","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pokfulam Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James\u00a0Chung\u00a0Man","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pokfulam Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David\u00a0Chi\u00a0Leung","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pokfulam Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan\u00a0Ling\u00a0Julie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pokfulam Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_12_2_1","DOI":"10.1183\/09031936.00012415"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1097\/ACI.0000000000000028"},{"doi-asserted-by":"publisher","key":"e_1_2_12_4_1","DOI":"10.1055\/s-0042-1743290"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1164\/rccm.200609-1346OC"},{"doi-asserted-by":"publisher","key":"e_1_2_12_6_1","DOI":"10.1007\/s00408-018-0188-5"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.1378\/chest.07-1177"},{"doi-asserted-by":"publisher","key":"e_1_2_12_8_1","DOI":"10.1183\/13993003.02288-2021"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1088\/1752-7163\/ab0ece"},{"doi-asserted-by":"publisher","key":"e_1_2_12_10_1","DOI":"10.2147\/JAA.S274022"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.2500\/ar.2014.5.0099"},{"doi-asserted-by":"publisher","key":"e_1_2_12_12_1","DOI":"10.1016\/j.mjafi.2021.01.018"},{"doi-asserted-by":"publisher","key":"e_1_2_12_13_1","DOI":"10.5603\/ARM.a2022.0015"},{"doi-asserted-by":"publisher","key":"e_1_2_12_14_1","DOI":"10.21037\/jtd.2020.04.01"},{"doi-asserted-by":"publisher","key":"e_1_2_12_15_1","DOI":"10.3109\/02770903.2011.611958"},{"doi-asserted-by":"publisher","key":"e_1_2_12_16_1","DOI":"10.1590\/1984-0462\/;2018;36;1;00015"},{"unstructured":"Global Initiative for Asthma \u201cGlobal Strategy for Asthma Management and Prevention; 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