{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:18:15Z","timestamp":1783099095962,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Lung abscess is a common disease in respiratory medicine, which is a suppurative lesion caused by various pathogens, and microbiological examination is crucial for the treatment of lung abscess. Due to the widespread use of antibiotics, it is difficult to obtain reliable microbiological evidence through routine tests. There are various pathogens present in the oral cavity, and periodontitis is a risk factor for the formation of lung abscess. Enhancing understanding of lung abscesses caused by <jats:styled-content style=\"fixed-case\"><jats:italic>Porphyromonas gingivalis<\/jats:italic><\/jats:styled-content> and the importance of accurately interpreting NGS reports. This article will present a case report of a lung abscess related to oral bacteria (<jats:styled-content style=\"fixed-case\"><jats:italic>Porphyromonas gingivalis<\/jats:italic><\/jats:styled-content>). The patient was initially treated with empirical anti\u2010infective therapy, which was ineffective, and despite multiple sputum cultures and bronchoalveolar lavage fluid analysis using metagenomic next\u2010generation sequencing (mNGS), the pathogen could not be identified clearly. However, based on the significant presence of oral bacteria in the NGS of the bronchoalveolar lavage fluid, which guided the examination to discover periodontitis. Subsequently, a percutaneous lung tissue biopsy was performed for NGS testing, which further suggested <jats:styled-content style=\"fixed-case\"><jats:italic>Porphyromonas gingivalis<\/jats:italic><\/jats:styled-content> as the pathogenic bacterium. This article summarizes the clinical manifestations, imaging findings, and characteristics of the pathogenic microorganisms in this case of lung abscess, reviews relevant literature to enhance the understanding of lung abscess caused by <jats:styled-content style=\"fixed-case\"><jats:italic>Porphyromonas gingivalis<\/jats:italic><\/jats:styled-content>. It also confirms the importance of careful analysis of background bacteria in bronchoalveolar lavage fluid NGS based on objective risk factors, and highlights that combining patient clinical features with multisample NGS examination can promptly clarify the microbiology.<\/jats:p>","DOI":"10.1111\/crj.70099","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:44:29Z","timestamp":1752731069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Pulmonary Abscess Caused by <scp><i>Porphyromonas gingivalis<\/i><\/scp> Infection: A Case Report and Literature Review"],"prefix":"10.1111","volume":"19","author":[{"given":"Xu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pulmonology Shanxi Provincial Hospital of Traditional Chinese Medicine  Taiyuan Shanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The First People's Hospital of Shuangliu District  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9897-1989","authenticated-orcid":false,"given":"Jiajia","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100949\u20107414"},{"key":"e_1_2_10_3_1","article-title":"Lung Abscess\u2010Etiology, Diagnostic and Treatment Options","volume":"3","author":"Kuhajda I.","year":"2015","journal-title":"Annals of Translational Medicine"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000001058"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534666211003012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.15449"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"244","article-title":"Potential Role of Periodontal Infection in Respiratory Diseases\u2014A Review","volume":"6","author":"Bansal M.","year":"2013","journal-title":"Journal of Medicine and Life"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2023.116126"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2022.e01458"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13684"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00053"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010012\u20101710\u2010y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130369"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.50"},{"issue":"5","key":"e_1_2_10_15_1","first-page":"608","article-title":"Prevalencia de Enfermedad Periodontal Grave (EPG) y su Asociaci\u00f3n con Enfermedades Respiratorias en Pacientes Adultos Hospitalizados en un Centro de Tercer Nivel [Prevalence of Severe Periodontal Disease and Its Association With Respiratory Disease in Hospitalized Adult Patients in a Tertiary Care Center]","volume":"151","author":"Fern\u00e1ndez\u2010Plata R.","year":"2015","journal-title":"Gaceta M\u00e9dica de M\u00e9xico"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12091110"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.10.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb\u20102022\u20100172"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10\u20100460"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2016.11.006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj7040114"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00017"},{"key":"e_1_2_10_23_1","first-page":"197","volume-title":"Oral Microbiology With Basic Microbiology and Immunology","author":"Nolte W. 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