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We aimed to systematically review the research advances of distal lung epithelial progenitors via lineage tracing strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The distal lung, including bronchioles and alveoli, carries the respiratory function and is the central region involved in acute respiratory distress syndrome and other diseases. Many endogenous epithelial stem cell\/progenitor lineages such as Club cells, alveolar type II cells, bronchioalveolar stem cells, and basal\u2010like progenitors that contribute to distal lung regeneration have been identified and are engaged in repairing lung injury for various reasons. Advances in lineage tracing technology have provided tremendous support in characterizing progenitor lineages, identifying new progenitor cell lineages, and discovering regulators of their behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The important role of distal lung epithelial progenitors and lineage tracing methods has been highlighted in recent years. Relevant studies provide a perspective for further deepening lineage tracing in lung progenitor research and laying the groundwork for endogenous stem cell therapies in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.70143","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T06:09:50Z","timestamp":1764482990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lineage Tracing of Distal Lung Epithelial Progenitors in Injury\u2010Induced Regeneration"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0280-3632","authenticated-orcid":false,"given":"Jian","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianchang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqi","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-6631","authenticated-orcid":false,"given":"Yuanlin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Shanghai Institute of Infectious Disease and Biosecurity, Fudan University  Shanghai China"},{"name":"Shanghai Respiratory Research Institute  Shanghai China"},{"name":"National Clinical Research Center for Aging and Medicine Huashan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Chemical Injury, Emergency and Critical Medicine of Shanghai Municipal Health Commission, Center of Emergency and Critical Medicine Jinshan Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"issue":"2","key":"e_1_2_14_2_1","first-page":"S46","article-title":"Cell Turnover in the Lung","volume":"128","author":"Bowden D. 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