{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:04:44Z","timestamp":1779789884390,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ60591"],"award-info":[{"award-number":["2025JJ60591"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ81728"],"award-info":[{"award-number":["2026JJ81728"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the epidemiological profile, coinfection spectrum, and virus\u2013virus association patterns between rhinovirus (RV; A\/B\/C) and influenza A virus (IAV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed 8928 respiratory samples collected from April 2023 to December 2025. A quality\u2010controlled RV analytic cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009386) and an IAV\u2010positive cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009422) were used for subtype distribution, coinfection profiling, and observed\u2010versus\u2010expected co\u2010occurrence analysis. Associations were evaluated with Fisher's exact test or chi\u2010square test, with odds ratios (ORs) and 95% confidence intervals (CIs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the RV cohort, subtype A was dominant (235\/386, 60.9%), followed by C (118\/386, 30.6%) and B (33\/386, 8.5%); mixed subtypes accounted for 1.6% (6\/386). Coinfection was common (282\/386, 73.1%), and IAV was detected in 14\/386 RV\u2010positive samples. Co\u2010occurrence analysis showed lower\u2010than\u2010expected overlap for IAV\u2010RV A (0.23% vs. 0.40%), IAV\u2010RV B (0.029% vs. 0.099%), and IAV\u2010RV A\/B\/C overall (0.390% vs. 0.624%), while IAV\u2010RV C was close to random expectation (0.217% vs. 0.210%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RV and IAV exhibited subtype\u2010dependent interaction patterns in this regional cohort, with apparent mutual exclusion for RV\u2010A\/RV\u2010B and near\u2010random coexistence for RV\u2010C. These findings support subtype\u2010stratified surveillance and season\u2010specific prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.70184","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:00:13Z","timestamp":1778641213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Characteristics and Co\u2010Detection Patterns of Rhinovirus (A\/B\/C) and Influenza A Virus in a Regional Respiratory Cohort in Hunan, China"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-1862","authenticated-orcid":false,"given":"Feicheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Bai","sequence":"additional","affiliation":[{"name":"Medical College Hunan Normal University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical College Hunan Normal University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juqi","family":"Peng","sequence":"additional","affiliation":[{"name":"Medical College Hunan Normal University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03376\u201025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.20180"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70399"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2025.110610"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.70300"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2025.106312"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14010141"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00108\u2010019\u201000672\u20104"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262110393"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018\u20100220OC"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020159"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2023.04.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095113"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010025\u201003178\u2010w"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01161\u201024"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2022.100147"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14102141"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.731846"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15102032"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11111320"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/379833"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7090726"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt205"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.294"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1521763"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2025.2469643"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13313"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006770"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00019\u201023"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12206465"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S389263"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.70184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.70184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.70184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T09:31:21Z","timestamp":1779787881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.70184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/crj.70184"],"URL":"https:\/\/doi.org\/10.1111\/crj.70184","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70184"}}