{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:04:42Z","timestamp":1779789882039,"version":"3.53.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prone positioning (PP) is established for the management of hypoxemic respiratory failure (HRF) due to acute respiratory distress syndrome (ARDS). However, its effectiveness in patients with HRF unrelated to ARDS remains unclear. This systematic review and meta\u2010analysis aimed to evaluate the clinical outcomes of PP in patients with non\u2010ARDS HRF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Cochrane Library, Web of Science, and EMBASE (up to February 2025) for observational studies and randomized controlled trials (RCTs) evaluating PP in patients with HRF unrelated to ARDS. We included studies that enrolled either intubated or non\u2010intubated patients. On the other hand, we excluded studies that combined PP with other positions and those that did not compare pre\u2010and\u2010post prone or did not have control groups. Two reviewers working independently screened the included studies and extracted the relevant data. Meta\u2010analyses using a random\u2010effects model were performed using the Review Manager software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one studies comprising 3040 patients with HRF unrelated to ARDS were included. Thirteen were observational studies, one was a non\u2010randomized clinical trial, and seven were RCTS. In non\u2010intubated patients, PP improved PaO2\/FiO2 compared with baseline (mean difference [MD]: \u221251.36\u2009mmHg; 95% CI: \u221270.39 to \u221232.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001), decreased the need for intubation compared with control\/standard care (risk ratio [RR]: 0.74; 95% CI: 0.60\u20130.91;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), and demonstrated a trend to improve mortality (RR: 0.81; 95% CI: 0.61\u20131.01;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07). In intubated non\u2010ARDS HRF patients, the PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio was higher after PP, but not statistically significant (MD: \u221229.84; 95% CI: \u221277.51 to 17.83;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.22).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In non\u2010intubated patients with HRF unrelated to ARDS, PP improved oxygenation and decreased the need for invasive ventilation without increasing mortality risk. Therefore, PP is likely an effective therapy for non\u2010intubated patients with non\u2010ARDS HRF. Furthermore, evidence suggests that PP can improve oxygenation in intubated patients with HRF unrelated to ARDS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.70190","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:01:08Z","timestamp":1778821268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Prone Positioning in Non\u2010ARDS Patients With Hypoxemic Respiratory Failure: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-7088","authenticated-orcid":false,"given":"Hany A.","family":"Zaki","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Hamad Medical Corporation  Doha Qatar"},{"name":"College of Medicine Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Yigit","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hamad Medical Corporation  Doha Qatar"},{"name":"Blizard Institute Queen Mary University  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman E.","family":"Shaban","sequence":"additional","affiliation":[{"name":"Department of Cardiology Al Jufairi Diagnosis and Treatment, MOH  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Shaban","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mansoura University Hospital  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shaban","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mansoura General Hospital  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5522-6010","authenticated-orcid":false,"given":"Mohamed Gafar","family":"Abdelrahim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-304X","authenticated-orcid":false,"given":"Mohamed","family":"Abosamak","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Elkandow","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Chaabna","sequence":"additional","affiliation":[{"name":"Institute for Population Health Weill Cornell Medicine\u2010Qatar  Education City Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03108-w"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.5.1602"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/08850666211014480"},{"key":"e_1_2_10_5_1","unstructured":"B. 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