{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:04:42Z","timestamp":1779789882112,"version":"3.53.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"publisher","award":["1595\/UN6.3.1\/PT.00\/2021"],"award-info":[{"award-number":["1595\/UN6.3.1\/PT.00\/2021"]}],"id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"publisher","award":["3855\/UN.C\/LT\/2019"],"award-info":[{"award-number":["3855\/UN.C\/LT\/2019"]}],"id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Linezolid effectively treats rifampicin\u2010resistant tuberculosis (RR\u2010TB) but can cause significant hematological toxicities linked to mitochondrial dysfunction in hematopoietic stem cells. Growth differentiation factor\u201015 (GDF\u201015) has been identified as a potential biomarker of this dysfunction. This study aimed to determine whether baseline GDF\u201015 levels can predict myelosuppression in RR\u2010TB patients treated with linezolid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included patients with RR\u2010TB from three referral hospitals who were treated with a linezolid\u2010containing regimen for at least 4\u2009weeks. Hematological parameters and GDF\u201015 levels were measured at baseline as well as at the 2nd and 4th\u20138th\u2009weeks of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010seven subjects were included in this study. By the 2nd week of linezolid treatment, GDF\u201015 levels significantly increased from a baseline of 635.58 (407.31\u20131583.65) to 708.96 (378.09\u20132408.89)pg\/ml (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). By weeks 4\u20138, 65% of patients developed myelosuppression. A correlation was found between baseline GDF\u201015 levels and hemoglobin reduction at weeks 4\u20138 (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Baseline GDF\u201015 levels &gt;\u2009950\u2009pg\/mL identified patients with more than a 25% reduction in hemoglobin (AUC 0.756, 95% CI 0.659\u20130.838).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline GDF\u201015 levels were correlated with hemoglobin changes during the 4th\u20138th\u2009weeks of linezolid treatment. These levels can predict myelosuppression, particularly hemoglobin changes, in patients with RR\u2010TB undergoing long\u2010term linezolid therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.70195","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:57:12Z","timestamp":1778241432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growth Differentiation Factor\u201015 Could Predict Decreased Hemoglobin in Tuberculosis Treated With Linezolid\u2010Containing Regimen"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7853-2221","authenticated-orcid":false,"given":"Amaylia","family":"Oehadian","sequence":"first","affiliation":[{"name":"Hematology and Medical Oncology Division, Department of Internal Medicine Dr. Hasan Sadikin General Hospital\/Faculty of Medicine, Universitas Padjadjaran  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prayudi","family":"Santoso","sequence":"additional","affiliation":[{"name":"Pulmonology and Critical Respiratory Division, Department of Internal Medicine Dr. Hasan Sadikin General Hospital\/Faculty of Medicine, Universitas Padjadjaran  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delita","family":"Prihatni","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Dr. Hasan Sadikin Hospital  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andini","family":"Kartikasari","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Division, Department of Internal Medicine Dr. Hasan Sadikin General Hospital\/Faculty of Medicine, Universitas Padjadjaran  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-589X","authenticated-orcid":false,"given":"Ida","family":"Parwati","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Dr. Hasan Sadikin Hospital  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diah","family":"Handayani","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, National Center of Respiratory Persahabatan Hospital, Universitas Indonesia Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Handoyo","sequence":"additional","affiliation":[{"name":"Pulmonology and Critical Respiratory Division, Department of Internal Medicine Dr. Kariadi General Hospital\/Faculty of Medicine, Universitas Diponegoro  Semarang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorwati","family":"Sutandiyo","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Division Dharmais Hospital\/Faculty of Medicine, Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachti","family":"Alisjahbana","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Disease Division, Department of Internal Medicine Dr. Hasan Sadikin General Hospital\/Faculty of Medicine, Universitas Padjadjaran  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Menzies","sequence":"additional","affiliation":[{"name":"Mc Gill International TB Center Montreal Chest Institute Research Institute of the McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rovina","family":"Ruslami","sequence":"additional","affiliation":[{"name":"Pharmacology Division, Department of Biomedical Science Universitas Padjadjaran  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Global Tuberculosis Report","author":"AD A. 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