{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:58:40Z","timestamp":1785221920406,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["[2022] 468"],"award-info":[{"award-number":["[2022] 468"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["[2023] 2"],"award-info":[{"award-number":["[2023] 2"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n \n Mycoplasma pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n (MP) is a major cause of community\u2010acquired pneumonia in children, with increasing macrolide resistance complicating treatment. Traditional Chinese Medicine (TCM) provides unique benefits for pediatric respiratory infections.\n <\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n \n To evaluate the safety and efficacy of Lianhua Qingke (LHQK) tablets as adjunctive therapy in children with\n \n M. pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n pneumonia (MPP).\n <\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n This prospective, multicenter, randomized, double\u2010blind, placebo\u2010controlled trial adhered to the Declaration of Helsinki and was registered in the Chinese Clinical Trial Registry (ChiCTR2300078209).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 160 children aged 4\u201314\u2009years with mild MPP were randomized 1:1 to receive conventional therapy plus LHQK or conventional therapy plus placebo for 7\u2009days across 13 hospitals over 4\u2009months. Efficacy analysis included 128 participants with centrally confirmed MP infection; safety analysis included all 160. Baseline characteristics were comparable (all\n p<\/jats:italic>\n \u2009>\u20090.05), with 98.8% medication compliance in both groups (\n p<\/jats:italic>\n \u2009>\u20090.05). The primary outcome was the major symptom resolution rate by Day 7.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The LHQK group showed a significantly higher major symptom resolution rate (85.9% vs. 65.6%,\n p<\/jats:italic>\n \u2009<\u20090.05), with a numerically shorter median time to resolution (4.5 vs. 5.0\u2009days,\n p<\/jats:italic>\n \u2009=\u20090.072). LHQK also significantly improved cough and expectoration relief rates (all\n p<\/jats:italic>\n \u2009<\u20090.05). No differences were found in laboratory parameters. Adverse event incidence was lower with LHQK (2.5% vs. 8.8%,\n p<\/jats:italic>\n \u2009>\u20090.05), with no serious events reported.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n LHQK is a safe and effective adjunctive TCM therapy for mild MPP in children, offering significant benefits in respiratory symptom alleviation and a favorable safety profile, with a trend toward shorter recovery time, providing a valuable treatment option amid rising antibiotic resistance.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/crj.70204","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:00:04Z","timestamp":1782450004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Lianhua Qingke Tablets in Children With\n Mycoplasma pneumoniae<\/i>\n Pneumonia: A Randomized, Double\u2010Blind, Multicenter, Placebo\u2010Controlled Clinical 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