{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:58:40Z","timestamp":1785221920969,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Accurate diagnosis of peripheral pulmonary lesions (PPLs) remains challenging. Conventional forceps biopsy frequently yields small samples compromised by crush artifact. Transbronchial cryobiopsy (TBCB) offers larger, better\u2010preserved specimens. This study evaluated the diagnostic yield and safety of radial endobronchial ultrasound (r\u2010EBUS)\u2010guided TBCB using a 1.1\u2010mm cryoprobe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This prospective single\u2010center study enrolled 73 consecutive patients with PPLs. Procedures were performed under general anesthesia using a laryngeal mask airway, a flexible bronchoscope, r\u2010EBUS for localization, and a 1.1\u2010mm cryoprobe inserted through a guide sheath. A prophylactic bronchial balloon blocker was employed for hemorrhage control. The primary outcome was diagnostic yield; secondary outcomes included bleeding severity and pneumothorax incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean lesion diameter was 21\u2009mm, with 79.5% of patients exhibiting a positive bronchus sign. A definitive histological diagnosis was established in 55 of 73 patients (75.3%). Malignancies accounted for 60.3% of diagnoses, whereas benign etiologies, including tuberculosis, represented 15.1%. Bleeding occurred in 19.2% of cases; all events were mild and managed with the balloon blocker. No severe hemorrhage was observed. Pneumothorax occurred in six patients (8.2%), with four requiring chest tube drainage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>r\u2010EBUS\u2010guided TBCB using a 1.1\u2010mm cryoprobe is feasible and effective for diagnosing PPLs, with a diagnostic yield of 75.3%. Protocolized use of a balloon blocker effectively prevents severe hemorrhagic complications. Pneumothorax risk warrants vigilance, particularly in patients with infectious cavitary disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.70216","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:47:06Z","timestamp":1784803626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Performance of Radial EBUS\u2010Guided Cryobiopsy for Peripheral Lung Lesions: First Experience in Morocco"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3891-9405","authenticated-orcid":false,"given":"Lamya","family":"Chrif Morand","sequence":"first","affiliation":[{"name":"Interventional Pulmonology Division International Hospital Kenitra Akdital  Kenitra Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Bouti","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Mohammed VI General University Hospital  Tangier Morocco"},{"name":"Laboratory of Life and Health Sciences, Faculty of Medicine and Pharmacy of Tangier Abdelmalek Essa\u00e2di University  T\u00e9touan Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Saidi","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, UM6P Hospitals University Mohammed VI Polytechnic  Benguerir Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumia","family":"Fdil","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Mohammed VI General University Hospital  Tangier Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-6348","authenticated-orcid":false,"given":"Anis","family":"Rafik","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Military Mohamed V Hospital  Rabat 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