{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:06:26Z","timestamp":1790215586004,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>High\u2010altitude exposure and hypoxia may induce a hypercoagulable state, thereby promoting the development of venous thromboembolism (VTE). Few studies have reported the incidence of VTE among patients with severe community\u2010acquired pneumonia (SCAP) in high\u2010altitude regions. We conducted a study to investigate the prevalence, risk factors, prognosis, and potential thromboprophylaxis strategies of VTE in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled 158 adult patients with SCAP admitted to Lhasa People's Hospital between January 1, 2023, and December 31, 2024. All patients underwent lower extremity venous compression ultrasound and\/or computed tomography pulmonary angiography examination. Clinical characteristics, including demographic information, medical history, vital signs, laboratory findings, treatments, complications, and clinical outcomes, were compared for patients with and without VTE in these two subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 158 patients, 74 (46.8%) developed VTE, including 68 with DVT, 21 with pulmonary embolism (PE) and 15 with both DVT and PE. A total of 123 (77.8%) patients received VTE prophylaxis, and there was no significant difference in the incidence of VTE among the groups with different prophylactic measures (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.838). Multivariate logistic regression analysis showed an association between lower partial pressure of arterial oxygen (PaO\n                      <jats:sub>2<\/jats:sub>\n                      )\/fraction of inspired oxygen (FiO\n                      <jats:sub>2<\/jats:sub>\n                      ) ratio (PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratios \u2264\u2009160\u2009mmHg: odds ratio [OR]\u2009=\u20092.354, 95% confidence interval [CI] 1.025\u20135.406,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044), higher D\u2010dimer level (D\u2010dimer levels \u2265\u20093.0\u2009\u03bcg\/mL: OR\u2009=\u20092.901, 95% CI 1.329\u20136.334;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), longer bedridden time (bedridden times \u2265\u20093\u2009days: OR\u2009=\u20093.540, 95% CI 1.494\u20138.391,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), and the occurrence of VTE. A new prediction model including PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratios, D\u2010dimer levels, and bedridden times showed a better performance in predicting VTE (AUC\u2009=\u20090.886; 95% CI 0.826\u20130.931; sensitivity: 74.3%; specificity: 89.3%) than Padua prediction score (AUC\u2009=\u20090.624) and Caprini prediction score (AUC\u2009=\u20090.622) for patients with SCAP at high\u2010altitude areas (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The calibration curve of the nomogram model shows good predictive value. The 30\u2010day cumulative survival rate of patients with VTE was significantly lower than that of patients without VTE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of VTE is unexpectedly high in hospitalized patients with SCAP in high\u2010altitude regions and may be associated with a poor prognosis. Early identification of patients at high risk for VTE and optimization of thromboprophylactic strategies are therefore warranted improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.70230","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:06:11Z","timestamp":1789106771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Venous Thromboembolism in Severe Community\u2010Acquired Pneumonia at High\u2010Altitude Areas: Prevalence, Risk and Outcome"],"prefix":"10.1111","volume":"20","author":[{"given":"Yuntao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Lhasa People's Hospital  Lhasa Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1435-5692","authenticated-orcid":false,"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Lhasa People's Hospital  Lhasa Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Lhasa People's Hospital  Lhasa Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Lhasa People's Hospital  Lhasa Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghe","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Lhasa People's Hospital  Lhasa Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingya","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Lhasa People's Hospital  Lhasa Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwangmu","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Lhasa People's Hospital  Lhasa Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-6737","authenticated-orcid":false,"given":"Yuanhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Lhasa People's Hospital  Lhasa Tibet China"},{"name":"Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"},{"name":"Department of Beijing Key Laboratory of Multimodal Intelligent Diagnosis and Treatment System for Respiratory Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68474-2"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.09.020"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-00974-8"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci10020030"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00160-7"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1363598"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107663"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1779016"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.5867\/medwave.2023.11.2719"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00377-2021"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00536-9"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-05630-1"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038922"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-021-00325-3"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2023.05.013"},{"issue":"4","key":"e_1_2_14_17_1","first-page":"197","article-title":"Thrombosis as a Complication of Extended Stay at High Altitude","volume":"14","author":"Anand A. 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