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More patients were maintained on 2000\u00a0mg with enteric\u2010coated mycophenolate sodium (<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>) vs. mycophenolate mofetil (month 6, 52.7% vs. 43.0% [p\u00a0=\u00a00.02]; month 12, 47.3% vs. 39.4% [p\u00a0=\u00a00.08]). Multivariate modeling showed no significant effect of baseline<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>dose on 12\u2010month risk of biopsy\u2010proven acute rejection, graft loss or estimated<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>, or on safety events including<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>discontinuation other than a higher rate of gastrointestinal adverse events in patients with an initial<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>dose &gt;2000\u00a0mg (p\u00a0=\u00a00.029) vs. 2000\u00a0mg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that an initial<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>dose of &lt;2000\u00a0mg does not compromise 12\u2010month efficacy in tacrolimus\u2010treated kidney transplants, but controlled trials are required and the lower threshold for<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>dose remains to be defined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12035","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T07:51:59Z","timestamp":1351842719000},"source":"Crossref","is-referenced-by-count":9,"title":["Association of mycophenolic acid dose with efficacy and safety events in kidney transplant patients receiving tacrolimus: an analysis of the Mycophenolic acid Observational REnal transplant registry"],"prefix":"10.1111","volume":"26","author":[{"given":"Cataldo","family":"Doria","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery Thomas Jefferson University Hospital Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Greenstein","sequence":"additional","affiliation":[{"name":"Department of Surgery Montefiore Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanram","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Department of Medicine Scott and White Memorial Hospital Temple TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimi","family":"Ueda","sequence":"additional","affiliation":[{"name":"The Barry S. 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