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Vasopressin is a hormone secreted by the posterior pituitary gland, which contributes to maintain systemic blood pressure by regulating urine secretion and small arteriole tonus. During brain death, the pituitary gland is damaged and hormone secretion rapidly ceases. Low\u2010dose vasopressin increases systemic blood pressure and decreases the need for catecholamines in brain\u2010dead organ donors but it is not available in many countries. Terlipressin is a synthetic analog of vasopressin characterized by greater selectivity for the <jats:styled-content style=\"fixed-case\">V1<\/jats:styled-content> receptor than vasopressin. To date, the efficacy of terlipressin as a pressor agent in humans has been reported in a few studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Pharmacology and literature about the use of <jats:styled-content style=\"fixed-case\">t<\/jats:styled-content>erlipressin in shock and in particularly in neurogenic shock following brain death is summarized and our personal experience is reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusion<\/jats:title><jats:p>Terlipressin is helpful in controlling severe hypotension; its use allowed to reduce the infusion rate of norepinephrine about 50% in two of three brain\u2010death organ donors, but there are not yet enough data to define its therapeutic range and incidence of collateral effects on the 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