{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:08:38Z","timestamp":1782940118002,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T00:00:00Z","timestamp":1355270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Overall 42 patients (pts) transplanted in hematological <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>1 were retrospectively analyzed. Median follow\u2010up was 15\u00a0months (range 2\u201377). The expression of <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1 gene was measured according to the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eukaemia <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>et recommendations. At the time of allogeneic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) 29 pts were <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1\u2010negative and 13 pts were <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1\u2010positive. In the univariate analysis, significantly better results were observed in the group of <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1 neg in terms of progression\u2010free survival (in three\u00a0yr 77% vs. 27%, p\u00a0=\u00a00.001). In multivariate analysis, the only significant feature in terms of better <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1 negativity (p\u00a0=\u00a00.029). Our results show that minimal residual disease status measured by quantitative assessment of <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1 gene in acute myeloid leukemia pts in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>1 significantly affects their future prognosis after allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ctr.12046","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T12:22:37Z","timestamp":1355401357000},"source":"Crossref","is-referenced-by-count":18,"title":["Minimal residual disease detectable by quantitative assessment of <scp>WT<\/scp>1 gene before allogeneic stem cell transplantation in patients in first remission of acute myeloid leukemia has an impact on their future prognosis"],"prefix":"10.1111","volume":"27","author":[{"given":"Veronika","family":"V\u00e1lkov\u00e1","sequence":"first","affiliation":[{"name":"Department of Bone Marrow Transplantation Institute of Haematology and Blood Transfusion Prague Czech Rep"},{"name":"Institute of Experimental Haematology First Faculty of Medicine Charles University Prague Czech Rep"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Pol\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Institute of Haematology and Blood Transfusion Prague Czech Rep"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marketa","family":"Markov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation Institute of Haematology and Blood Transfusion Prague Czech Rep"},{"name":"Institute of Experimental Haematology First Faculty of Medicine Charles University Prague Czech Rep"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"V\u00edtek","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation 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