{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:57:05Z","timestamp":1782449825287,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrence of focal segmental glomerulosclerosis (<jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>) in pediatric kidney allografts is associated with poor graft survival. Several therapeutic regimens have been proposed, with conflicting results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten pediatric patients with recurrent <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> after kidney transplantation were treated with a protocol of methylprednisolone (<jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>) infusions in combination with cyclosporine (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>)\u2010based immunosuppression. The patients received a drug regimen with infusions of 20\u00a0mg\/kg <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> on three consecutive days at week 1, week 3, and week 5, and then monthly until six\u00a0months after transplantation. If a complete or partial remission (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) was obtained, <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> pulse continued every three\u00a0months until 24\u00a0months after transplantation. The <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> dose was adjusted according to <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>0\u20134.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven of 10 patients (70%) achieved complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) with stable renal function within 18\u00a0months of beginning of treatment. One of two patients with <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> entered <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> 3.5\u00a0yr after transplantation. One patient lost her graft due to recurrence four\u00a0months after transplantation. After observation for 26\u2013119\u00a0months, seven patients maintained remission with normal glomerular filtration rate. Few major side effects were observed in association with the high\u2010dose <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> infusion therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> infusion therapy in combination with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2010based immunosuppression could be safe and effective in treating recurrent <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> after kidney transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12079","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T06:14:25Z","timestamp":1360131265000},"source":"Crossref","is-referenced-by-count":33,"title":["Combination of pulse methylprednisolone infusions with cyclosporine\u2010based immunosuppression is safe and effective to treat recurrent focal segmental glomerulosclerosis after pediatric kidney transplantation"],"prefix":"10.1111","volume":"27","author":[{"given":"Seiichiro","family":"Shishido","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology School of Medicine Toho University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Satou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology and Kidney Transplantation Tokyo Metropolitan Kiyose Children's Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Toho University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology School of Medicine Toho University Tokyo 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