{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:40:40Z","timestamp":1768902040281,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>The aim of this study was to examine the impact of pre\u2010existing diabetes mellitus (DM<\/jats:styled-content>) on acute rejection, graft loss, and mortality following kidney transplant and whether glycemic control or cardiovascular disease (CVD<\/jats:styled-content>) risk control with medications influenced outcomes. This was a cohort study of 1002 renal transplants conducted between 2000 and 2008. Patients were included if they received a kidney transplant within the allotted time and were at least 18\u00a0yr of age. Cox regression was used to assess acute rejection, graft failure, or death controlling for relevant sociodemographic, clinical, and post\u2010transplant variables. Five\u2010yr patient survival (83% vs. 93%, p\u00a0<\u00a00.001) and graft survival (74% vs. 79%, p\u00a0=\u00a00.005) were significantly lower in patients with pre\u2010existing DM<\/jats:styled-content>. Sequential Cox regression models demonstrated that pre\u2010existing DM<\/jats:styled-content> was consistently associated with a higher risk of death (HR<\/jats:styled-content> 2.3\u20133.0, p\u00a0<\u00a00.01) and graft failure (HR<\/jats:styled-content> 1.5\u20131.8, p\u00a0<\u00a00.04) in all models except after adjusting for CVD<\/jats:styled-content> medication use (HR<\/jats:styled-content> 1.9, p\u00a0=\u00a00.174 and HR<\/jats:styled-content> 1.5, p\u00a0=\u00a00.210, respectively). These data suggest pre\u2010existing DM<\/jats:styled-content> is a significant risk factor for graft failure and death following renal transplantation and aggressive CVD<\/jats:styled-content> risk reduction with medications may be an important strategy to reduce mortality and graft failure.<\/jats:p>","DOI":"10.1111\/ctr.12080","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T06:15:00Z","timestamp":1360131300000},"page":"274-282","source":"Crossref","is-referenced-by-count":48,"title":["Pre\u2010existing diabetes significantly increases the risk of graft failure and mortality following renal transplantation"],"prefix":"10.1111","volume":"27","author":[{"given":"David J.","family":"Taber","sequence":"first","affiliation":[{"name":"Division of Transplant Surgery Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly B.","family":"Meadows","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole A.","family":"Pilch","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Chavin","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhakar K.","family":"Baliga","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard E.","family":"Egede","sequence":"additional","affiliation":[{"name":"College of Medicine Center for Healthcare Disparities Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,6]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Diabetes Statistics.American Diabetes Association.http:\/\/www.diabetes.org\/diabetes-basics\/diabettes-statistics. Accessed February 24 2012."},{"key":"e_1_2_5_3_1","unstructured":"Scientific Registry of Transplant Recipients.http:\/\/www.ustransplant.org. Accessed March 21 2012."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.06.027"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02101.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2010.01159.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00010.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590600620792"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S4235"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32832a7b01"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc096250"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcq165"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339909788920901"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-S011"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00359.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339911796397857"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V71158"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","author":"ADVANCE Collaborative G","year":"2008","journal-title":"N Engl J Med"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806470"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(96)00030-X"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.08.0401"},{"key":"e_1_2_5_23_1","first-page":"132","article-title":"[Beta\u2010adrenolitics in therapy of cardiovascular diseases in patients with type 2 diabetes mellitus]","volume":"64","author":"Krupej J","year":"2011","journal-title":"Wiad Lek"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820437bd"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12080","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T14:49:19Z","timestamp":1697640559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,6]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/ctr.12080"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12080","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,6]]}}}