{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T05:05:35Z","timestamp":1700629535685},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic hepatitis B is prevalent in the transplant setting and may cause significant complications. Effective control of viral replication is needed. Besides lamivudine, very little data are available on safety and efficacy of other drugs. We describe our experience with adefovir dipivoxil (<jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content>) in eight heart transplant recipients. Studies included a baseline liver biopsy, thrice\u2010monthly clinical, biochemical, and virological evaluations, including genotyping and viral load, polymerase gene sequencing for resistance mutations, liver and kidney function tests, and liver ultrasound. Of eight patients, six had fibrosis score \u22642 and negative <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg and seven had hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) genotype D. Upon <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> start, median <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was 5.8 logs\u00a0IU\/mL and alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) levels were mostly normal. All patients had prior mild\u2010to\u2010moderate renal functional impairment. Seven of eight patients started <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> after a previous course of lamivudine. Five of these seven patients became <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> undetectable within eight\u00a0months. One patient with low baseline viremia started <jats:styled-content style=\"fixed-case\">ADV <\/jats:styled-content><jats:italic>de novo<\/jats:italic> and suppressed <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>. Median treatment duration was 66\u00a0months. <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> daily dose was halved in one patient due to renal function worsening. No <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> flares, hypophosphatemia, liver decompensation, liver cancer, or emergence of resistance was observed. Our data suggest that <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> may be a safe and effective rescue treatment for heart transplant recipients with lamivudine\u2010resistant chronic hepatitis B.<\/jats:p>","DOI":"10.1111\/ctr.12109","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T07:36:40Z","timestamp":1363851400000},"source":"Crossref","is-referenced-by-count":4,"title":["Adefovir treatment for chronic hepatitis B in heart transplant recipients"],"prefix":"10.1111","volume":"27","author":[{"given":"Emanuele","family":"Durante\u2010Mangoni","sequence":"first","affiliation":[{"name":"Internal Medicine Section Department of Cardiothoracic Sciences University of Naples SUN, and Unit of Transplant Medicine Monaldi Hospital Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Iossa","sequence":"additional","affiliation":[{"name":"Internal Medicine Section Department of Cardiothoracic 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