{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:42:02Z","timestamp":1780472522064,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granzyme B (<jats:styled-content style=\"fixed-case\">GZMB<\/jats:styled-content>) and perforin 1 gene (<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>1) are key effector molecules of cytotoxic T lymphocytes, in causing acute and chronic solid organ transplant rejection. In this study, we analyzed the impact of<jats:styled-content style=\"fixed-case\">GZMB<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>1 polymorphism on kidney allograft outcomes. In all, 527<jats:italic>de novo<\/jats:italic>kidney Hispanic allograft recipients were genotyped for<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>1 (rs10999426, rs35947132) and<jats:styled-content style=\"fixed-case\">GZMB<\/jats:styled-content>(rs8192917, rs7144366).<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>1 (rs10999426, rs35947132) G alleles and<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>genotypes were negatively associated with allograft rejection, demonstrating protection against allograft rejection (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.61, p\u00a0=\u00a00.005 for rs1099946;<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.4, p\u00a0=\u00a00.01 for rs 35947132). On the other hand, the<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>heterozygosity of<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>1 was found marginally associated with the rejection group (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.53, p\u00a0=\u00a00.05 for rs10999426;<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.24, p\u00a0=\u00a00.07 for rs35947132). There was a significant increase in allograft survival in time period studied for the<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>1 (rs10999426)<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>genotype, while the<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>heterozygosity was associated with graft failure. We found no association for polymorphic markers in<jats:styled-content style=\"fixed-case\">GZMB<\/jats:styled-content>gene with allograft rejection. Survival was significantly improved for patients who were homozygous<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>for the<jats:styled-content style=\"fixed-case\">GZMB<\/jats:styled-content>(rs8192917) (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>vs.<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>, p\u00a0=\u00a00.041). The result suggests that<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>1 and<jats:styled-content style=\"fixed-case\">GZMB<\/jats:styled-content>gene polymorphisms may determine the incidence of acute rejection or graft survival among Hispanic allograft recipients.<\/jats:p>","DOI":"10.1111\/ctr.12114","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T07:16:49Z","timestamp":1364282209000},"source":"Crossref","is-referenced-by-count":5,"title":["Association between granzyme<scp>B<\/scp>and perforin<scp>I<\/scp>polymorphisms and allograft outcomes in Hispanic kidney transplant recipients"],"prefix":"10.1111","volume":"27","author":[{"given":"Eglis","family":"Corrales\u2010Tellez","sequence":"first","affiliation":[{"name":"Nova Southeastern University Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Vu","sequence":"additional","affiliation":[{"name":"Mendez National Institute of Transplantation Los Angeles CA USA"},{"name":"Western University of Health Sciences Pomona CA USA"},{"name":"Saint Vincent Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Shah","sequence":"additional","affiliation":[{"name":"Western University of Health Sciences Pomona CA USA"},{"name":"Saint Vincent Medical Center Los Angeles CA USA"},{"name":"University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Mendez National Institute of Transplantation Los Angeles CA USA"},{"name":"University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Min","sequence":"additional","affiliation":[{"name":"Western University of Health Sciences Pomona CA USA"},{"name":"Saint Vincent Medical Center Los Angeles CA 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