{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:49:11Z","timestamp":1791305351825,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,28]],"date-time":"2013-04-28T00:00:00Z","timestamp":1367107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Scarce data exist regarding the incidence of donor\u2010specific antibodies (\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    s) in kidney transplant patients receiving everolimus\u2010based immunosuppression without calcineurin inhibitors (\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    s). The aim of this retrospective case\u2013control study was to compare the incidence of\n                    <jats:italic>de novo<\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    s in patients converted to an everolimus\u2010based regimen without\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    s with that seen in patients maintained on\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    s. Sixty\u2010one\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    \u2010free kidney transplant patients who had been converted to an everolimus\u2010based regimen (everolimus group) were compared to 61 other patients maintained on\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    s\u2010based regimen (control group). Patients were matched according to age, gender, induction therapy, date of transplantation, and being\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    \u2010free at baseline. At last follow\u2010up, the incidence of\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    s was 9.8% in the everolimus group and 5% in the control group (p\u00a0=\u00a0ns). In the everolimus group, the increased incidence of\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    s between baseline and last follow\u2010up was statistically significant. Antibody\u2010mediated rejection occurred in 6.5% in the everolimus group and 0% in the\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    s group. The incidence of\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    s is numerically increased in kidney transplant patients treated with an everolimus\u2010based without\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    s. A study including a larger number of patients is required to determine whether a\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    \u2010free everolimus\u2010based immunosuppression significantly increases\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    s formation.\n                  <\/jats:p>","DOI":"10.1111\/ctr.12127","type":"journal-article","created":{"date-parts":[[2013,4,28]],"date-time":"2013-04-28T23:11:08Z","timestamp":1367190668000},"page":"455-462","source":"Crossref","is-referenced-by-count":48,"title":["Incidence of donor\u2010specific antibodies in kidney transplant patients following conversion to an everolimus\u2010based calcineurin inhibitor\u2010free regimen"],"prefix":"10.1111","volume":"27","author":[{"given":"Nassim","family":"Kamar","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil Toulouse France"},{"name":"Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"INSERM U1043 IFR\u2013BMT CHU Purpan Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Del Bello","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil Toulouse France"},{"name":"Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Congy\u2010Jolivet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"Department of Immunology CHU de Toulouse H\u00f4pital de Rangueil Toulouse France"},{"name":"Molecular Immunogenetics Laboratory Facult\u00e9 de M\u00e9decine Purpan Universit\u00e9 Paul Sabatier IFR150 (INSERM) Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Guilbeau\u2010Frugier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"Department of Histopathology CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Cardeau\u2010Desangles","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylise","family":"Fort","sequence":"additional","affiliation":[{"name":"Department of Immunology CHU de Toulouse H\u00f4pital de Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Guitard","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Gam\u00e9","sequence":"additional","affiliation":[{"name":"Department of Urology and Kidney Transplantation CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Rostaing","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil Toulouse France"},{"name":"Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"INSERM U1043 IFR\u2013BMT CHU Purpan Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60699-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009101065"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02104.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02577.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e11798"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.492"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03637.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181927a41"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005090993"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62318-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03961.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02987.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03129.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318224c12d"},{"issue":"4","key":"e_1_2_6_16_1","first-page":"151","article-title":"Impact of early conversion at 3 months from cyclosporine (CsA) to sirolimus (SRL) in association with mycophenolate mofetil (MMF) on renal function \u2013 \u201cresults at 48 months of follow up of a multicenter randomized controlled trial: the concept study","volume":"10","author":"Lebranchu Y","year":"2010","journal-title":"Am J Transplant"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04159.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04158.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02798.x"}],"container-title":["Clinical 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