{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:56:29Z","timestamp":1792032989357,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:00:00Z","timestamp":1368057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antifungal prophylaxis is recommended in high\u2010risk patients, but risk criteria remain unclear and the predictive value of Model of End\u2010Stage Liver Disease (\n                    <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>\n                    ) score is unknown. In a retrospective, single\u2010center analysis of 667 liver transplants, potential risk factors for fungal infection were assessed, including\n                    <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>\n                    score. Antifungal prophylaxis was administered in 198 patients (29.4%). During follow\u2010up (mean 43.6\u00a0\u00b1\u00a029.6\u00a0months), 263 patients (39.4%) developed \u22651 episode of fungal infection, and 187 (28.0%) patients developed a probable or proven invasive fungal infection requiring systemic antifungal treatment. Patients receiving antifungal prophylaxis had a lower incidence of fungal infection (29.8% vs. 43.5% without prophylaxis, p\u00a0&lt;\u00a00.001) and invasive fungal infection (17.7% vs. 32.4%, p\u00a0&lt;\u00a00.001). One\u2010yr patient survival was 91%, 85% and 69%, respectively, in patients with no fungal infection, fungal colonization and treated invasive fungal infection (p\u00a0&lt;\u00a00.001); graft survival was 88%, 85% and 66% (p\u00a0&lt;\u00a00.001). Multivariate analysis indicated that\n                    <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>\n                    score of 20\u201330 or \u226530 was associated with a 2.0\u2010fold or 4.3\u2010fold increase in relative risk of fungal infection, respectively, and a 2.1\u2010fold or 3.1\u2010fold increase in relative risk of invasive fungal infection. In conclusion, liver transplant patients with a\n                    <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>\n                    score \u226520, and particularly patients with a score \u226530, are candidates for antifungal prophylaxis.\n                  <\/jats:p>","DOI":"10.1111\/ctr.12129","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T03:37:25Z","timestamp":1368070645000},"source":"Crossref","is-referenced-by-count":103,"title":["Fungal infections after liver transplantation: outcomes and risk factors revisited in the\n                    <scp>MELD<\/scp>\n                    era"],"prefix":"10.1111","volume":"27","author":[{"given":"Faouzi","family":"Saliba","sequence":"first","affiliation":[{"name":"AP\u2010HP H\u00f4pital Paul Brousse Centre H\u00e9pato\u2010Biliaire Villejuif France"},{"name":"Universit\u00e9 Paris\u2010Sud UMR\u2010S 785 Villejuif France"},{"name":"Inserm Unit\u00e9 785 Villejuif 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