{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:19:03Z","timestamp":1764173943188},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) is a major pathogen affecting solid organ transplant (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) recipients. Prophylactic strategies have decreased the rate of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection\/disease among <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>. However, data on the effect of current prophylactic strategies for simultaneous pancreas\u2013kidney (<jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content>) or pancreas after kidney (<jats:styled-content style=\"fixed-case\">PAK<\/jats:styled-content>) transplant remain limited. We report our experience of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> prophylaxis in <jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PAK<\/jats:styled-content> recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 130 post\u2010<jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PAK<\/jats:styled-content> patients were analyzed retrospectively for the rate of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> and the risk factors associated with the acquisition of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>. All patients received antiviral prophylaxis. The follow\u2010up period was one\u00a0yr post\u2010transplant or until death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> post\u2010<jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PAK<\/jats:styled-content> transplant was 24%, 44%, and 8.2% among the whole cohort, the D+\/R\u2212 and the R+ groups, respectively. Median time of prophylaxis was 49 (0\u2013254)\u00a0d. In the whole cohort, risk factors for <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection\/diseases were D+\/R\u2212 <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> status (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]\u00a0=\u00a016.075), preceding non\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> (infection caused by bacteria or fungi and other viruses) infection (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a06.362) and the duration of prophylaxis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.984). Among the <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> D+\/R\u2212 group, non\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection was the only risk factor for <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> disease (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a010.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Forty\u2010four per cent (25\/57) of the D+\/R\u2212 recipients developed <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection\/disease despite <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> prophylaxis. Current <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> prophylaxis failed to prevent <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection\/disease in this group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12138","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T12:25:42Z","timestamp":1370262342000},"page":"503-509","source":"Crossref","is-referenced-by-count":28,"title":["Cytomegalovirus infection post\u2010pancreas\u2013kidney transplantation \u2013 results of antiviral prophylaxis in high\u2010risk patients"],"prefix":"10.1111","volume":"27","author":[{"given":"Samira M.","family":"Fallatah","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max A.","family":"Marquez","sequence":"additional","affiliation":[{"name":"Multiorgan Transplant Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fateh","family":"Bazerbachi","sequence":"additional","affiliation":[{"name":"Multiorgan Transplant Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Schiff","sequence":"additional","affiliation":[{"name":"Multiorgan Transplant Department of Medicine Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Cattral","sequence":"additional","affiliation":[{"name":"Multiorgan Transplant Department of Surgery Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian D.","family":"McGilvray","sequence":"additional","affiliation":[{"name":"Multiorgan Transplant Department of Surgery Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Norgate","sequence":"additional","affiliation":[{"name":"Multiorgan Transplant Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Selzner","sequence":"additional","affiliation":[{"name":"Multiorgan Transplant Department of Surgery Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coleman","family":"Rotstein","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid","family":"Husain","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Toronto General Hospital University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03022.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200112270-00013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01207.x"},{"key":"e_1_2_6_5_1","volume-title":"Overview of Neutropenia","author":"Baehner 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