{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:13:53Z","timestamp":1778181233205,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nowadays, laparoscopic donor nephrectomy (<jats:styled-content style=\"fixed-case\">LDN<\/jats:styled-content>) has become the gold standard to procure live donor kidneys. As the relationship between donor and recipient loosens, it becomes of even greater importance to optimize safety and comfort of the surgical procedure. Low\u2010pressure pneumoperitoneum has been shown to reduce pain scores after laparoscopic cholecystectomy. Live kidney donors may also benefit from the use of low pressure during <jats:styled-content style=\"fixed-case\">LDN<\/jats:styled-content>. To evaluate feasibility and efficacy to reduce post\u2010operative pain, we performed a randomized blinded study. Twenty donors were randomly assigned to standard (14\u00a0mmHg) or low (7\u00a0mmHg) pressure during LDN. One conversion from low to standard pressure was indicated by protocol due to lack of progression. Intention\u2010to\u2010treat analysis showed that low pressure resulted in a significantly longer skin\u2010to\u2010skin time (149\u00a0\u00b1\u00a086 vs. 111\u00a0\u00b1\u00a019\u00a0min), higher urine output during pneumoperitoneum (23\u00a0\u00b1\u00a035 vs. 11\u00a0\u00b1\u00a020\u00a0mL\/h), lower cumulative overall pain score after 72\u00a0h (9.4\u00a0\u00b1\u00a03.2 vs. 13.5\u00a0\u00b1\u00a04.5), lower deep intra\u2010abdominal pain score (11\u00a0\u00b1\u00a03.3 vs. 7.5\u00a0\u00b1\u00a03.1), and a lower cumulative overall referred pain score (1.8\u00a0\u00b1\u00a01.9 vs. 4.2\u00a0\u00b1\u00a03). Donor serum creatinine levels, complications, and quality of life dimensions were not significantly different. Our data show that low\u2010pressure pneumoperitoneum during <jats:styled-content style=\"fixed-case\">LDN<\/jats:styled-content> is feasible and may contribute to increase live donors\u2019 comfort during the early post\u2010operative phase.<\/jats:p>","DOI":"10.1111\/ctr.12143","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T03:28:07Z","timestamp":1372130887000},"source":"Crossref","is-referenced-by-count":33,"title":["Low\u2010pressure pneumoperitoneum during laparoscopic donor nephrectomy to optimize live donors\u2019 comfort"],"prefix":"10.1111","volume":"27","author":[{"given":"M.C.","family":"Warl\u00e9","sequence":"first","affiliation":[{"name":"Division of Vascular\u2010 and Transplant Surgery Department of Surgery Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.W.","family":"Berkers","sequence":"additional","affiliation":[{"name":"Division of Vascular\u2010 and Transplant Surgery Department of Surgery Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F","family":"Langenhuijsen","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"van der Jagt","sequence":"additional","affiliation":[{"name":"Division of Vascular\u2010 and Transplant Surgery Department of Surgery Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ph.M.","family":"Dooper","sequence":"additional","affiliation":[{"name":"Department of Nephrology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.","family":"Kloke","sequence":"additional","affiliation":[{"name":"Department of Nephrology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pilzecker","sequence":"additional","affiliation":[{"name":"Department of Nephrology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Renes","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.E.","family":"Wever","sequence":"additional","affiliation":[{"name":"Division of Vascular\u2010 and Transplant Surgery Department of Surgery Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Hoitsma","sequence":"additional","affiliation":[{"name":"Department of Nephrology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"van der Vliet","sequence":"additional","affiliation":[{"name":"Division of Vascular\u2010 and Transplant Surgery Department of Surgery Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.C.H.","family":"D'Ancona","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD006124","article-title":"Laparoscopic versus open nephrectomy for live kidney donors","volume":"11","author":"Wilson CH","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","first-page":"CD006930","article-title":"Low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy","volume":"2","author":"Gurusamy KS","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00406-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004649901011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2008.9725"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000151662.84962.4E"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000055272.96210.A0"},{"key":"e_1_2_6_9_1","first-page":"205","article-title":"Effects of the application of intra\u2010abdominal low pressure on laparoscopic cholecystectomy on acid\u2010base equilibrium","volume":"94","author":"Karagulle E","year":"2009","journal-title":"Int Surg"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6651"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12143","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:08:47Z","timestamp":1696352927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/ctr.12143"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12143","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]}}}