{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T08:23:44Z","timestamp":1749457424259},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inhibitors of the mammalian target of rapamycin (<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>) have been associated with proteinuria. We studied the development of proteinuria in renal transplant recipients (<jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>) treated with the <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitor everolimus in comparison with a calcineurin inhibitor. We related the presence of proteinuria to histopathological glomerular findings in two\u2010yr protocol biopsies. In a single\u2010center study, nested in a multicenter randomized controlled trial, we determined <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>, proteinuria, and renal biopsy data (light\u2010 and electron microscopy) of <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content> receiving prednisolone\/everolimus (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EVL<\/jats:styled-content>) (n\u00a0=\u00a016) in comparison with patients treated with prednisolone\/cyclosporine A (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) (n\u00a0=\u00a07). All patients had been on the above\u2010described maintenance immunosuppression for 18\u00a0months. Renal function at two yr after transplantation did not differ between patients receiving <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EVL<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> 45.5 vs. 45.7\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>). Proteinuria was slightly increased in <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EVL<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> group (0.29 vs. 0.14\u00a0g\/24\u00a0h, p\u00a0=\u00a00.06). There were no differences in light\u2010 or electron microscopic findings. We could not demonstrate increased podocyte effacement or changes in glomerular basement membrane (<jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content>) thickness in <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EVL<\/jats:styled-content>\u2010treated patients. In conclusion, long\u2010term treatment with everolimus leaves the <jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content> and podocytes unaffected.<\/jats:p>","DOI":"10.1111\/ctr.12144","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T03:28:13Z","timestamp":1372130893000},"page":"535-540","source":"Crossref","is-referenced-by-count":9,"title":["Cyclosporine versus everolimus: effects on the glomerulus"],"prefix":"10.1111","volume":"27","author":[{"given":"Marije C.","family":"Baas","sequence":"first","affiliation":[{"name":"Renal Transplant Unit Division of Internal Medicine Department of Nephrology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Kers","sequence":"additional","affiliation":[{"name":"Department of Pathology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Florquin","sequence":"additional","affiliation":[{"name":"Department of Pathology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan W.","family":"de Fijter","sequence":"additional","affiliation":[{"name":"Department of Nephrology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap J.","family":"Homan van der Heide","sequence":"additional","affiliation":[{"name":"Renal Transplant Unit Division of Internal Medicine Department of Nephrology Groningen University Hospital Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius A.","family":"van den Bergh Weerman","sequence":"additional","affiliation":[{"name":"Department of Pathology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ineke J. 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