{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:06Z","timestamp":1791308706829,"version":"4.3.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited published data concerning the effects of different immunosuppressive regimens on the development of polyomavirus (<jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>) viremia. We examined the risk of developing <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viremia in kidney transplant recipients receiving everolimus (<jats:styled-content style=\"fixed-case\">EVR<\/jats:styled-content>) or mycophenolic acid (<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>) as maintenance therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We observationally analyzed 296 patients who underwent renal transplantation at our center between 2005 and 2010: 58 were treated with EVR and low\u2010dose cyclosporine (LD\u2010CyA) (group 1) and 238 with MPA and standard\u2010dose CyA (group 2). All of the patients received induction therapy with basiliximab and maintenance steroids. BKV viremia (a whole\u2010blood viral load of &gt;850\u00a0copies\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) was measured by means of real\u2010time polymerase chain reaction at least once a month during a 12\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BKV viremia was detected in 57 patients (19%), five (9%) in group 1 and 52 (22%) in group 2. Kaplan\u2013Meier analyses showed that freedom from BKV viremia was significantly more frequent in group 1. The mean time of onset of BKV viremia was about four\u00a0months after transplantation in both groups. The median viral load was greater in group 2 (12.5\u00a0\u00b1\u00a06.1 vs. 2.5\u00a0\u00b1\u00a01.8\u00a0\u00d7\u00a010<jats:sup>4<\/jats:sup>\u00a0copies\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>; p\u00a0=\u00a00.01). After the onset of BKV viremia, graft function significantly declined in group 2: 11 patients developed polyomavirus\u2010associated nephropathy (PVAN) and four presumptive PVAN; nine experienced an acute rejection after the discontinuation of MPA, and 11 (21%) lost their graft. There was no graft loss in group 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that in comparison with <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> and Cya, an <jats:styled-content style=\"fixed-case\">EVR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>\u2010CyA regimen lowers the risk of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viremia after kidney transplantation and favorably alters outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12151","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T07:45:32Z","timestamp":1371109532000},"page":"546-554","source":"Crossref","is-referenced-by-count":56,"title":["Everolimus leads to a lower risk of BKV viremia than mycophenolic acid in <i>de novo<\/i> renal transplantation patients: a single\u2010center experience"],"prefix":"10.1111","volume":"27","author":[{"given":"Luciano","family":"Moscarelli","sequence":"first","affiliation":[{"name":"Renal Unit Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Caroti","sequence":"additional","affiliation":[{"name":"Renal Unit Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Antognoli","sequence":"additional","affiliation":[{"name":"Renal Unit Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Zanazzi","sequence":"additional","affiliation":[{"name":"Renal Unit Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Di Maria","sequence":"additional","affiliation":[{"name":"Renal Unit Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Carta","sequence":"additional","affiliation":[{"name":"Renal Unit Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Minetti","sequence":"additional","affiliation":[{"name":"Renal Unit Careggi University Hospital Florence 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