{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:09:26Z","timestamp":1769584166219,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Organs available for solid organ transplantation are mainly procured from brain dead donors. The inflammation associated with brain death may reduce organ quality and increase organ immunogenicity, thus leading to inferior recipient outcome. We hypothesized that the extensive surgical procedure performed during multiorgan procurement enhances the levels of systemic inflammatory biomarkers. We measured the levels of 27 cytokines and the terminal complement complex (<jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content>) in plasma samples from brain dead organ donors (n\u00a0=\u00a034) drawn before and at three specific time points during procurement surgery. Baseline levels of <jats:styled-content style=\"fixed-case\">G\u2010CSF<\/jats:styled-content>, interferon\u2010\u03b3, <jats:styled-content style=\"fixed-case\">IL\u20101ra<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101, macrophage inflammatory protein (<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>)\u20101\u03b2, platelet derived growth factor (<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>), regulated upon activation <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cell expressed and secreted, and tumor necrosis factor\u2010\u03b1 were significantly elevated in brain dead donors compared with normal individuals (n\u00a0=\u00a014), but they were not associated with time on ventilator or any other registered clinical variable. Notably, the secretion of <jats:styled-content style=\"fixed-case\">G\u2010CSF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL1\u2010ra<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b2, <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content>, the latter reflecting ongoing complement activation, increased significantly during surgery. None of the biomarker increases were correlated with operation duration. Multiorgan procurement surgery significantly adds to the inflammatory response revealed by both pro\u2010 and anti\u2010inflammatory biomarkers associated with brain death. Future studies should determine whether this is associated with inferior recipient outcome.<\/jats:p>","DOI":"10.1111\/ctr.12175","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T07:59:06Z","timestamp":1372319946000},"page":"613-618","source":"Crossref","is-referenced-by-count":18,"title":["Multiorgan procurement increases systemic inflammation in brain dead donors"],"prefix":"10.1111","volume":"27","author":[{"given":"Henrik","family":"Aur\u00e5en","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom E.","family":"Mollnes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8ystein","family":"Bj\u00f8rtuft","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per A.","family":"Bakkan","sequence":"additional","affiliation":[{"name":"Department of Transplantation Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odd","family":"Geiran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Department of Cardiothoracic Surgery Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johny","family":"Kongerud","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnt","family":"Fiane","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Department of Cardiothoracic Surgery Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Are M.","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000100663.11852.BF"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01879.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)01876-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(02)00052-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318174d89f"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2005093"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00657.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330601"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01871.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05898.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01799.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0790161"},{"key":"e_1_2_6_14_1","first-page":"123","article-title":"The serum interleukin 6 response to elective surgery","volume":"8","author":"Shenkin A","year":"1989","journal-title":"Lymphokine Res"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066610395678"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199603000-00010"},{"issue":"5","key":"e_1_2_6_17_1","first-page":"456","article-title":"The role of interleukin\u20108 in inflammation and mechanisms of regulation","volume":"64","author":"Bickel M","year":"1993","journal-title":"J Periodontol"},{"key":"e_1_2_6_18_1","first-page":"121","article-title":"CXCL10\/IP\u201010 in infectious diseases pathogenesis and potential therapeutic implications","volume":"22","author":"Liu M","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.07.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2003.10.019"},{"key":"e_1_2_6_21_1","first-page":"431","article-title":"The role of complement in the early immune response to transplantation. 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