{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:19:22Z","timestamp":1792725562370,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac denervation following transplantation has a variable effect on heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>), and the consequence of this is not known. We examined the impact of first\u2010year <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> on five\u2010yr outcomes after heart transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 544 heart transplant recipients from 1994 to 2008. Patients were divided into groups by mean first\u2010year <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: group 1, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0&lt;\u00a090 (mean 85.0\u00a0\u00b1\u00a04.3); group 2, 90\u00a0\u2264\u00a0<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0&lt;\u00a0110 (mean 97.8\u00a0\u00b1\u00a04.9); group 3, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0\u2265\u00a0110 (mean 111.5\u00a0\u00b1\u00a01.8). Endpoints included one\u2010yr freedom from treated rejection, five\u2010yr survival, five\u2010yr freedom from cardiac allograft vasculopathy (<jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>), and five\u2010yr freedom from non\u2010fatal major adverse cardiac events (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010yr freedom from treated rejection, five\u2010yr survival and freedom from <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content> were not significantly different between groups. Five\u2010yr freedom from <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content> was significantly lower in group 3 compared with group 2, 69% vs. 91%, p\u00a0&lt;\u00a00.01, mainly due to higher prevalence of congestive heart failure (<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>) in group 3 over five\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mean first\u2010year <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> does not provide prognostic significance for one\u2010yr freedom from treated rejection, five\u2010yr survival or development of <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content> five\u00a0yr after heart transplant. These results suggest that <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> post\u2010heart transplantation does not affect long\u2010term outcomes, but high first\u2010year <jats:styled-content style=\"fixed-case\">HRs<\/jats:styled-content> may be associated with new\u2010onset <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12188","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T06:59:43Z","timestamp":1375945183000},"page":"659-665","source":"Crossref","is-referenced-by-count":11,"title":["The impact of mean first\u2010year heart rate on outcomes after heart transplantation: does it make a difference?"],"prefix":"10.1111","volume":"27","author":[{"given":"Ankit B.","family":"Shah","sequence":"first","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jignesh K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Rafiei","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Kittleson","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon A.","family":"Kobashigawa","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2506","article-title":"Endocrine response to exercise in cardiac transplant patients","volume":"19","author":"Schuler S","year":"1987","journal-title":"Transplant Proc"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3492"},{"key":"e_1_2_7_4_1","first-page":"358","volume-title":"Primer on Transplantation","author":"Kobashigawa JA","year":"2001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90183-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90450-2"},{"key":"e_1_2_7_7_1","first-page":"743","article-title":"The effect of chronic amiodarone therapy before transplantation on early cardiac allograft function","volume":"10","author":"Macdonald P","year":"1991","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_7_8_1","first-page":"387","article-title":"Redistribution of amiodarone in heart transplant recipients treated with the drug before operation","volume":"16","author":"Nanas JN","year":"1997","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00073.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.11.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.04.029"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.04.034"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.06.026"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017972129833"},{"issue":"5","key":"e_1_2_7_15_1","first-page":"IV313","article-title":"Bradyarrhythmia after heart transplantation. 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