{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:35:10Z","timestamp":1760783710380},"reference-count":37,"publisher":"Wiley","issue":"s25","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Familial amyloid polyneuropathy (<jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content>) is the most common subtype of hereditary amyloidosis. The amyloid protein transthyretin deposits as rigid amyloid fibers in the extracellular matrix of various tissues including peripheral nerves, heart, and gastrointestinal tract. As the mutated amyloid protein is mainly produced in the liver, one form of treatment to halt the progression of disease is liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>). This study was performed to identify risk factors for decreased overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 21 transplant patients who underwent <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> between 1996 and 2011 were analyzed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of patients had cardiac symptoms (76%), gastrointestinal symptoms (71%), or peripheral polyneuropathy (71%). A conventional operating technique was performed on 11 patients using end\u2010to\u2010end caval anastomoses, while the modified piggyback technique by Belghiti was performed on 10 patients. Overall survival analysis revealed a one\u2010yr survival rate of 74.3% and three\u2010 and five\u2010yr survival rates of 60.0% and 52.5%, respectively. Pre\u2010operative modified body mass index (<jats:styled-content style=\"fixed-case\">mBMI<\/jats:styled-content>) &lt;700\u00a0kg\u00a0g\/L\u00a0m\u00b2 and time interval between diagnosis and operation before LT resulted in significantly lower overall survival (p\u00a0=\u00a00.0137; p\u00a0=\u00a00.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pre\u2010operative nutritional status and time interval between diagnosis and operation before <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> influence overall survival after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for hereditary amyloidosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12193","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T10:29:03Z","timestamp":1375439343000},"page":"40-48","source":"Crossref","is-referenced-by-count":13,"title":["Modified body mass index and time interval between diagnosis and operation affect survival after liver transplantation for hereditary amyloidosis: a single\u2010center analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Clemens","family":"Franz","sequence":"first","affiliation":[{"name":"Department of General and Transplant Surgery Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of General and Transplant Surgery Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Hinz","sequence":"additional","affiliation":[{"name":"Department of General and Transplant Surgery Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of General and Transplant Surgery Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"},{"name":"Amyloidosis Center Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Hund","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"},{"name":"Department of Neurology Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel N.","family":"Gotthardt","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"},{"name":"Department of Gastroenterology Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Ganten","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"},{"name":"Department of Gastroenterology Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnt Volko","family":"Kristen","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"},{"name":"Department of Cardiology, Angiology and Pneumology Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Hegenbart","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg Germany"},{"name":"Department of Hematology, Oncology and Rheumatology Ruprecht\u2010Karls\u2010University Heidelberg Heidelberg 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