{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:58:57Z","timestamp":1791388737690,"version":"4.3.3"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought to assess the disutility associated with diabetes in the kidney transplant population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 233 kidney transplant recipients age 18\u201374 from a Midwestern hospital outpatient department. Recipients with multiple or multi\u2010organ transplants, those with laboratory evidence that suggests acute cellular damage (creatinine\u2010kinase\u00a0&gt;\u00a0200\u00a0U\/L), or a diagnosis of acute renal failure or acute rejection were excluded from the analysis (n\u00a0=\u00a033). Participants health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>) were evaluated using the Euro\u2010QoL\u20105 Dimension (<jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D), Health Utility Index Mark <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HUI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>), and the Short Form\u20106D (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u20106D), which was calculated from the generic section (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201012) of the Kidney Disease Quality of Life 36 (<jats:styled-content style=\"fixed-case\">KDQOL<\/jats:styled-content>\u201036). We estimated health utilities associated with diabetes using general linear modeling after adjusting for demographic, socioeconomic, and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The adjusted health disutilities associated with diabetes were clinically and statistically significant: EQ\u20105D (\u0394\u00a0=\u00a00.05; p\u00a0&lt;\u00a00.01), HUI\u2010III (\u0394\u00a0=\u00a00.09; p\u00a0&lt;\u00a00.01), and SF\u20106D (\u0394\u00a0=\u00a00.04, p\u00a0&lt;\u00a00.01). There was no difference between diabetic patients with good glycemic control (mean serum glucose &lt;126\u00a0mg\/dL in the three months prior to enrollment) and patients with poor glycemic control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among kidney transplant patients between the ages of 18\u201374, non\u2010diabetics have significantly higher <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> scores on the <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D, <jats:styled-content style=\"fixed-case\">HUI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u20106D compared with patients with diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12198","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T07:29:53Z","timestamp":1375342193000},"source":"Crossref","is-referenced-by-count":16,"title":["Health\u2010related quality of life in kidney transplant patients with diabetes"],"prefix":"10.1111","volume":"27","author":[{"given":"Jonathan L.","family":"Dukes","sequence":"first","affiliation":[{"name":"Center for Outcomes Research Saint Louis University School of Medicine St. Louis MO USA"},{"name":"Division of Infectious Diseases Washington University in St. Louis School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmitha","family":"Seelam","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research Saint Louis University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista L.","family":"Lentine","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research Saint Louis University School of Medicine St. Louis MO USA"},{"name":"Division of Nephrology Saint Louis University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research Saint Louis University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Neri","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e di Comunit\u00ec Universit\u00e0 degli Studi di Milano Milano Italy"},{"name":"Clinica del Lavoro Luigi Devoto Fondazione IRCCS Ca\u2019 Granda \u2010 Ospedale Maggiore Policlinico Milano 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