{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:19:43Z","timestamp":1778869183459,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T00:00:00Z","timestamp":1377907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Sirolimus (SRL<\/jats:styled-content>) has some dermatologic complications including acneiform eruptions, edema, aphthous ulceration, and onychopathy. However, controlled studies reporting the prevalence and clinical characteristics of mucocutaneous disorders are scarce.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the prevalence and clinical spectrum of mucocutaneous disorders in renal transplant recipients (RTR<\/jats:styled-content>s) receiving SRL<\/jats:styled-content> and to compare the findings with those in RTR<\/jats:styled-content>s not receiving SRL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fifty RTR<\/jats:styled-content>s (35 men, 15 women; mean age, 34.6\u00a0\u00b1\u00a011.6\u00a0yr) receiving SRL<\/jats:styled-content>, 50 RTR<\/jats:styled-content>s (36 men, 14 women; mean age, 34.4\u00a0\u00b1\u00a011.3\u00a0yr) not on SRL<\/jats:styled-content> were screened for mucocutaneous disorders.<\/jats:p><\/jats:sec>Results<\/jats:title>In RTR<\/jats:styled-content>s receiving SRL<\/jats:styled-content>, skin infection (78%) was the most common dermatologic disorder followed by facial hyperpigmentation (50%) and acneiform eruption (46%). Herpes simplex virus infections (14%) and seborrheic dermatitis (38%) were significantly more common in RTR<\/jats:styled-content>s on SRL<\/jats:styled-content> (p\u00a0<\u00a00.05); the frequencies of edema, aphthous ulceration, acne, and longitudinal nail ridging were similar in both groups (p\u00a0>\u00a00.05).<\/jats:p><\/jats:sec>Limitations<\/jats:title>This study had a small sample size. The investigator was not blinded to immunosuppressive treatment protocols.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Renal transplant recipients receiving SRL<\/jats:styled-content> are more likely to develop seborrheic dermatitis and herpes simplex virus infections than those not taking SRL<\/jats:styled-content>. Whereas, they are not more prone to edema, aphthous ulceration, acne, or longitudinal nail ridging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12215","type":"journal-article","created":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T04:38:47Z","timestamp":1377923927000},"page":"742-748","source":"Crossref","is-referenced-by-count":10,"title":["Mucocutaneous disorders in renal transplant recipients receiving sirolimus\u2010based immunosuppressive therapy: a prospective, case\u2013control study"],"prefix":"10.1111","volume":"27","author":[{"given":"Deren","family":"\u00d6zcan","sequence":"first","affiliation":[{"name":"Department of Dermatology Ba\u015fkent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Se\u00e7kin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ba\u015fkent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Ada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ba\u015fkent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Haberal","sequence":"additional","affiliation":[{"name":"Department of General Surgery Ba\u015fkent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.05.021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767030-00004"},{"issue":"8","key":"e_1_2_7_4_1","first-page":"61","article-title":"Sirolimus in renal transplantation","volume":"22","author":"Morath C","year":"2007","journal-title":"Nephrol Dial 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