{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:41:56Z","timestamp":1780375316599,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the incidence and long\u2010term outcomes of squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) of the bladder in patients after kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 1976 and March 2013, five patients from one center (0.0013%) developed <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the bladder after undergoing a deceased donor kidney transplant. Their relevant risk factors included long\u2010term self\u2010intermittent catheterization\/indwelling catheter (n\u00a0=\u00a02), smoking history (n\u00a0=\u00a02), and a prior history of cyclophosphamide treatment for vasculitis (n\u00a0=\u00a01). Primary outcome variables were overall patient survival and latency period between transplantation and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The duration of long\u2010term follow\u2010up was 94\u00a0\u00b1\u00a089 (range: 4\u2013239) months. The latency period between transplantation and bladder <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> was 87\u00a0\u00b1\u00a087 (range: 2\u2013228) months, and all five patients were immunosuppressed with tacrolimus, mycophenolate mofetil, and prednisone. Four patients had suspected metastases upon presentation, and one patient presented with organ\u2010confined disease. This patient underwent a radical cystectomy and remains disease free eight\u00a0months post\u2010operatively. Despite radical treatment, the remaining four patients died from metastatic disease 7\u00a0\u00b1\u00a04.4 (range: 2\u201311) months after their initial diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the bladder has a poor prognosis particularly in renal transplant patients. Early detection with flexible cystourethroscopy in patients with risk factors for <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> may improve long\u2010term outcomes in this patient cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12245","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:21:21Z","timestamp":1381749681000},"source":"Crossref","is-referenced-by-count":10,"title":["Incidence and long\u2010term outcomes of squamous cell bladder cancer after deceased donor renal transplantation"],"prefix":"10.1111","volume":"27","author":[{"given":"N. F.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Urology and Transplant Surgery Beaumont Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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