{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:39:34Z","timestamp":1792521574752,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>After cardiac transplant, there is often development of restrictive cardiac physiology. Little is known about the factors that contribute to this physiology and its correlation with pathology. Heart retransplantation provides a valuable opportunity to further understand this relationship. In this study, we investigated the correlation of myocardial fibrosis and restrictive physiology, and possible risk factors utilizing data from all retransplants at our center. A retrospective review of the 30 patients who underwent retransplantation at our institution between 1994 and 2004 was performed. Hemodynamic and imaging data were reviewed for the presence of restrictive physiology. Pathology reports were reviewed for the presence of myocardial fibrosis in the explanted hearts. The cohort with restrictive physiology preceding redo heart transplant had significantly more patients exhibiting myocardial fibrosis compared with the non\u2010restrictive physiology group (94.1% vs. 15.4%, p\u00a0&lt;\u00a00.001). We found no difference in the immunosuppressive regimen, history of rejection, and reason for transplant. In our study, we observed that myocardial fibrosis is an important contributor to the development of restrictive physiology. Further work needs to be done for risk stratification and the mechanism of fibrosis development.<\/jats:p>","DOI":"10.1111\/ctr.12250","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T12:31:28Z","timestamp":1381235488000},"source":"Crossref","is-referenced-by-count":50,"title":["Correlation between myocardial fibrosis and restrictive cardiac physiology in patients undergoing retransplantation"],"prefix":"10.1111","volume":"27","author":[{"given":"Jon A.","family":"Kobashigawa","sequence":"first","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Heart Transplant Program Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon K.","family":"Itagaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kaiser Permanente Los Angeles Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia R.","family":"Razi","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Heart Transplant Program Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jignesh K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Heart Transplant Program Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxing","family":"Chai","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Heart Transplant Program Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Kawano","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Heart Transplant Program Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Heart Transplant Program Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Kittleson","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Heart Transplant Program Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Fishbein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine UCLA Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200008270-00013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.02.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000661"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.108.838367"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.542894"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.05.038"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00296-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.01087.x"},{"key":"e_1_2_7_10_1","first-page":"587","article-title":"A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. 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