{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:29:12Z","timestamp":1761895752858,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000690","name":"Research Councils UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The amount of irreversible injury on renal allograft biopsy predicts function, but little is known about the early evolution of this damage. In a single\u2010center cohort, we examined the relationship between donor\u2010, recipient\u2010, and transplantation\u2010associated factors and change in a morphometric index of chronic damage (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>) between protocol biopsies performed at implantation and at 2\u20133\u00a0months. We then investigated whether early delta <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> predicted subsequent biochemical outcomes. We found little evidence to support differences between the study group, who had undergone serial biopsies, and a contemporaneous control group, who had not. In allografts with serial biopsies (n\u00a0=\u00a0162), there was an increase in <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> between implantation (median: 2%, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>:0\u20138) and 2\u20133\u00a0months post\u2010transplant (median 8% <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>:4\u201315; p\u00a0&lt;\u00a00.0001). Donation from younger or live donors was independently associated with smaller early post\u2010transplant increases in <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>. There was no evidence for a difference in delta <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> between donation after cardiac death vs. donation after brain death, nor association with length of cold ischemia. After adjustment for <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> at the time of the second biopsy, delta <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> after three\u00a0months did not predict allograft function at one\u00a0yr. These findings suggest that graft damage develops shortly after transplantation and reflects donor factors, but does not predict future biochemical outcomes.<\/jats:p>","DOI":"10.1111\/ctr.12251","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:20:59Z","timestamp":1381544459000},"source":"Crossref","is-referenced-by-count":5,"title":["Early changes in scores of chronic damage on transplant kidney protocol biopsies reflect donor characteristics, but not future graft function"],"prefix":"10.1111","volume":"27","author":[{"given":"Ben","family":"Caplin","sequence":"first","affiliation":[{"name":"Centre for Nephrology UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Veighey","sequence":"additional","affiliation":[{"name":"Centre for Nephrology UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arundathi","family":"Mahenderan","sequence":"additional","affiliation":[{"name":"Renal and Transplant Unit Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Manook","sequence":"additional","affiliation":[{"name":"Renal and Transplant Unit Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Henry","sequence":"additional","affiliation":[{"name":"Renal and Transplant Unit Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Nitsch","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Epidemiology Faculty of Epidemiology and Population Health London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Harber","sequence":"additional","affiliation":[{"name":"Renal and Transplant Unit Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dupont","sequence":"additional","affiliation":[{"name":"Renal and Transplant Unit Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Centre for Nephrology UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Jones","sequence":"additional","affiliation":[{"name":"Renal and Transplant Unit Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bimbi","family":"Fernando","sequence":"additional","affiliation":[{"name":"Renal and Transplant Unit Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Howie","sequence":"additional","affiliation":[{"name":"Department of Pathology University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Veitch","sequence":"additional","affiliation":[{"name":"Renal and Transplant Unit Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"U.S. Department of Health and Human Services H.R.a.S.A. Healthcare Systems Bureau Division of Transplantation Rockville MD. Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data1999\u20132008.2009."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00424.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00332.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01050.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00811.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000054496.68498.13"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000120177.44144FF"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ff4f7f"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03594.x"},{"key":"e_1_2_6_11_1","unstructured":"NHS Blood and Transplant Organ Donation and Transplantation.Patient selection and allocation policies. Kidney transplantation: organ allocation.2013. Available at:http:\/\/www.odt.nhs.uk\/pdf\/kidney_allocation_policy.pdf"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-4-200608150-00004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00086.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67046-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03312.x"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12251","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.12251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:13:13Z","timestamp":1696396393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,9]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/ctr.12251"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12251","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2013,10,9]]}}}