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Although it is well known that chronic renal allograft dysfunction or failure is caused by various immunological or non\u2010immunological factors, donor\u2010specific anti\u2010human leukocyte antigen antibodies (<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>s) are considered to be the most detrimental to graft survival and could cause C\u2010<jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>. Despite the use of intensive treatment for C\u2010<jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>, outcomes have not always been promising. Recently, prevention, rather than treatment, of C\u2010<jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> has been attempted, and this approach appears to be a more effective option for reducing the incidence of C\u2010<jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> and, ultimately, improving long\u2010term survival. To prevent C\u2010<jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>, removal of antibodies, inactivation of antibodies, and prevention of antibody production after kidney transplantation are essential. Preconditioning treatment including plasmapheresis, intravenous immunoglobulin, and rituximab injection seems the most effective of current desensitization protocols. In this minireview, we will focus on the prevention of C\u2010<jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> through desensitization and improving long\u2010term graft survival.<\/jats:p>","DOI":"10.1111\/ctr.12260","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T14:43:49Z","timestamp":1386168229000},"page":"2-8","source":"Crossref","is-referenced-by-count":3,"title":["Desensitization for prevention of chronic antibody\u2010mediated rejection after kidney transplantation"],"prefix":"10.1111","volume":"27","author":[{"given":"Kazunari","family":"Tanabe","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Inui","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo 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