{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:33:55Z","timestamp":1761489235565},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cell transplantation in paraplegic patients is beginning, but scarce attention is paid to the morphology of lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We studied using magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) the morphology of the injured spinal cord in 200 patients with chronic and complete paraplegia after spinal cord injury (<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>) at the thoracic level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When it was possible to undertake a correct study of the lesion, approximately 35% of patients had images showing spinal cord transection or showed fine tracts of tissue that connected both edges of a virtually transected spinal cord. Approximately 30% of patients had significant kyphosis with chronic spinal cord compression, and approximately 5% of cases had extensive spinal cord atrophy. In only approximately 30% of the patients, <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> revealed a centromedullary cavity, which was generally limited to the level of the vertebral fracture, and failed to show any apparent spinal cord transection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Humans suffering from chronically established paraplegia show a great variability of lesions, which differs from the standardized images of <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content> obtained in animal models. When we design clinical trials, our goal should be to achieve a correct selection of patients, and the morphology of the spinal cord must be one of the main factors to consider.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12267","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T06:07:26Z","timestamp":1382422046000},"page":"968-971","source":"Crossref","is-referenced-by-count":10,"title":["Cell transplantation in paraplegic patients: the importance of properly assessing the spinal cord morphology"],"prefix":"10.1111","volume":"27","author":[{"given":"Jes\u00fas","family":"Vaquero","sequence":"first","affiliation":[{"name":"Neuroscience Research Unit of Neurosurgical Department Hospital Puerta de Hierro\u2010Majadahonda Rafael del Pino Chair and UAM\u2010Los Madro\u00f1os Hospital Chair Autonomous University Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Zurita","sequence":"additional","affiliation":[{"name":"Neuroscience Research Unit of Neurosurgical Department Hospital Puerta de Hierro\u2010Majadahonda Rafael del Pino Chair and UAM\u2010Los Madro\u00f1os Hospital Chair Autonomous University Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200405190-00004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.03.069"},{"key":"e_1_2_6_4_1","first-page":"107","article-title":"Bone marrow stromal cells for spinal cord injury: a challenge for contemporary neurobiology","volume":"24","author":"Vaquero J","year":"2009","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.12.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318186198f"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-011-0076-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31824387f9"},{"key":"e_1_2_6_9_1","first-page":"241","article-title":"Autologous bone marrow derived mononuclear cell therapy for spinal cord injury: a phase I\/II clinical safety and primary efficacy data","volume":"7","author":"Kumar AA","year":"2009","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3727\/000000006783464381"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0807"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12267","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:14:42Z","timestamp":1696396482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,22]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/ctr.12267"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12267","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,22]]}}}