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In this study, we present a detailed description of the cohort, of characteristic changes over the observation period, proteinuria and graft survival, and new\u2010onset proteinuria after conversion. Over the study period, age, graft function at the time of conversion, and the proportion of patients switched to sirolimus because of malignancy increased, whereas the proportion of patients with significant proteinuria at conversion decreased. Already modest proteinuria (151\u2013268\u00a0mg\/L) at conversion and new\u2010onset proteinuria (&gt;500\u00a0mg\/L) after conversion were associated with inferior graft survival. Even mild proteinuria (&gt;71\u00a0mg\/L) at conversion was associated with new\u2010onset proteinuria (&gt;500\u00a0mg\/L) post\u2010conversion. Serum creatinine and urinary protein excretion at conversion together with age at transplantation had a significant impact on patient and graft survival. This large data set confirms and extends previous observations that proteinuria is an important indicator for graft outcome after conversion to sirolimus. We conclude that patients without any proteinuria have the greatest benefit from conversion to sirolimus.<\/jats:p>","DOI":"10.1111\/ctr.12280","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T12:19:24Z","timestamp":1388060364000},"page":"67-79","source":"Crossref","is-referenced-by-count":13,"title":["Proteinuria and sirolimus after renal transplantation: a retrospective analysis from a large <scp>G<\/scp>erman multicenter database"],"prefix":"10.1111","volume":"28","author":[{"given":"Marcel G.","family":"Naik","sequence":"first","affiliation":[{"name":"Department of Nephrology Charit\u00e9 University \u2013 Mitte Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina M.","family":"Heller","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Erlangen Erlangen 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