{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:49:41Z","timestamp":1760820581982},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A recent report has demonstrated that as with mycophenolate mofetil (<jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>), everolimus is capable of inhibiting human B\u2010lymphocyte function and activation including B\u2010lymphocyte proliferation, apoptosis, and immunoglobulin production <jats:italic>in vitro<\/jats:italic>. Everolimus may therefore be used as an immunosuppressant in <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A three\u2010month pilot study was performed to examine the efficacy and safety of conversion of stable <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible kidney transplant recipients from <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> with standard exposure calcineurin inhibitors (<jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>s) to everolimus with very low exposure <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>s. Sixteen recipients were enrolled in the study. The patients without acute rejection by graft biopsy were switched from <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> to everolimus with <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> minimization. At three\u00a0months after conversion, graft biopsies were performed to check for acute rejection and C4d deposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Conversion to everolimus with <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> minimization for three\u00a0months did not induce acute rejection and C4d deposition in all of the <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible kidney transplant recipients. A slight elevation of anti\u2010A\/B antibody titer occurred in our present study. Everolimus was associated with hyperlipidemia and edema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrated that short\u2010term conversion from <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> to everolimus after one\u00a0yr post\u2010transplant may be a safe and effective alternate for <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible kidney transplant recipients requiring temporary discontinuation of <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12281","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T05:04:52Z","timestamp":1386824692000},"page":"80-87","source":"Crossref","is-referenced-by-count":15,"title":["Conversion of stable <scp>ABO<\/scp>\u2010incompatible kidney transplant recipients from mycophenolate mofetil with standard exposure calcineurin inhibitors (CNIs) to everolimus with very low exposure CNIs\u2013a short\u2010term pilot study"],"prefix":"10.1111","volume":"28","author":[{"given":"Junji","family":"Uchida","sequence":"first","affiliation":[{"name":"Department of Urology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Machida","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka City University Graduate School of Medicine Osaka 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