{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:20:25Z","timestamp":1791408025700,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective was to use the United States Renal Data System (<jats:styled-content style=\"fixed-case\">USRDS<\/jats:styled-content>) to quantify the relationship between immunosuppressant therapy (<jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content>) adherence and risk of graft failure among adult renal transplant recipients (<jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s). A secondary objective was to examine the relationship among select patient characteristics and <jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content> adherence. The study sample included adult <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s who: received primary transplant between January 1, 1999 and December 31, 2005; experienced graft survival for at least 12\u00a0months post\u2010transplant and had at least 12\u00a0months of data in the <jats:styled-content style=\"fixed-case\">USRDS<\/jats:styled-content>; utilized Medicare coverage for <jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content>; and were prescribed cyclosporine or tacrolimus. <jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content> adherence was measured by medication possession ratio (<jats:styled-content style=\"fixed-case\">MPR<\/jats:styled-content>). Pearson chi\u2010square tests were used to examine associations between patient characteristics and <jats:styled-content style=\"fixed-case\">MPR<\/jats:styled-content> quartiles. Cox proportional hazards regression was used to assess relationships among time to graft failure, <jats:styled-content style=\"fixed-case\">MPR<\/jats:styled-content>, and patient characteristics. Thirty\u2010one thousand nine hundred and thirteen <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s met inclusion criteria. Older age, female gender, white race, deceased donors, and tacrolimus were associated with greater adherence (p\u00a0&lt;\u00a00.001). Cox proportional hazard modeling indicated greater adherence, white race, and having a living donor were significantly associated with longer graft survival (p\u00a0&lt;\u00a00.05). Future prospective studies should further examine the clinical significance of <jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content> nonadherence as it relates to graft failure.<\/jats:p>","DOI":"10.1111\/ctr.12283","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T05:05:12Z","timestamp":1386824712000},"page":"96-104","source":"Crossref","is-referenced-by-count":59,"title":["Determining the effect of immunosuppressant adherence on graft failure risk among renal transplant recipients"],"prefix":"10.1111","volume":"28","author":[{"given":"Christina A.","family":"Spivey","sequence":"first","affiliation":[{"name":"College of Pharmacy University of Tennessee Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie A.","family":"Chisholm\u2010Burns","sequence":"additional","affiliation":[{"name":"College of Pharmacy University of Tennessee Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Damadzadeh","sequence":"additional","affiliation":[{"name":"Zuckerman College of Public Health University of Arizona Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Billheimer","sequence":"additional","affiliation":[{"name":"College of Agriculture and Life Sciences BIO5 Institute University of Arizona Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000258599.65257.a6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00537.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01966.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02798.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199511000-00006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000287189.33074.c8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"21s","DOI":"10.1016\/S0041-1345(99)00118-9","article-title":"Late renal allograft loss: noncompliance masquerading as chronic rejection","volume":"31","author":"Gaston R","year":"1999","journal-title":"Transplant Proc"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03840.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a236e0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01966.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2011.01589.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2008.00820.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp040541"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01611.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2005.00183.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199301000-00010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209173271203"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199301000-00010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199812270-00026"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm149"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1073-4449(97)70016-5"},{"key":"e_1_2_8_23_1","first-page":"39","article-title":"Noncompliance with immunosuppressive medications after renal transplant","volume":"1","author":"Ghods AJ","year":"2003","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070630"},{"key":"e_1_2_8_25_1","unstructured":"United Network for Organ Sharing (UNOS).Data collection. 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