{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:27:43Z","timestamp":1782854863783,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1K08DK092282-01"],"award-info":[{"award-number":["1K08DK092282-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alloantibody can lead to antibody\u2010mediated rejection and graft loss in renal transplantation, necessitating an assessment of cross\u2010match compatibility. Within the past decade, more specific solid phase assays of alloantibody have been widely adopted, allowing virtual cross\u2010matching based on unacceptable antigens, the threshold of which is determined by individual centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the clinical outcomes of 482 patients transplanted 2007\u20132009 in a single center, focusing on 30 patients with weakly reactive donor\u2010specific antibody (<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>) determined prospectively prior to renal transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with patients without <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>, patients with weakly reactive <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> do not have increased rates of antibody\u2010mediated rejection, cellular rejection, or graft loss despite conventional immunosuppression utilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using the screening methodology and immunosuppression regimen, we have applied to the patients with weak <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> allows them to be transplanted with equivalent outcomes as those without <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>, despite the overall higher risk characteristics of the patients in the weak <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12289","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T11:40:19Z","timestamp":1387366819000},"page":"127-133","source":"Crossref","is-referenced-by-count":13,"title":["Clinical outcomes among renal transplant recipients with pre\u2010transplant weakly reactive donor\u2010specific antibodies"],"prefix":"10.1111","volume":"28","author":[{"given":"Peter S.","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Surgery Section of Transplantation and Immunology Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bonnel","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplant Surgery Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Kamoun","sequence":"additional","affiliation":[{"name":"Department of Pathology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew H.","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplant Surgery Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200210270-00025"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196904032801401"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03340.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200301150-00008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e328331c169"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009101065"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01944.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl202"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32832d31c7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816b1c37"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02072.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0635-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.06.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.04.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00299.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00072.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02813.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a5e034"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr429"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03364.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02701.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03093.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a44206"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12289","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:26:18Z","timestamp":1696335978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,18]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/ctr.12289"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12289","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,18]]}}}