{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:13:32Z","timestamp":1778825612122,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association between serum uric acid and kidney graft and recipient survival is uncertain. During 2000\u20132011, we measured serum uric acid at week 10 after transplantation. Of 2748 transplanted patients, 2200 (80.1%) attended this visit. After a median follow\u2010up of 7.4\u00a0yr, 378 patients had died, 143 from a cardiovascular cause, and 185 patients lost their graft. The third quintile of uric acid levels (357\u2013405\u00a0\u03bcM) had the lowest mortality risk and was used as reference group. In Cox proportional hazard models adjusting for graft and patient characteristics, the fifth quintile of uric acid levels (&gt;474\u00a0\u03bcM) was independently associated with cardiovascular mortality (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>]\u00a0=\u00a02.87 [1.55\u20135.32], p\u00a0=\u00a00.001) and all\u2010cause mortality (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.57 [1.09\u20132.25], p\u00a0=\u00a00.02). Also, the lowest quintile of uric acid levels (&lt;309\u00a0\u03bcM) showed a trend toward increased risk of cardiovascular mortality (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.79 [0.90\u20133.58], p\u00a0=\u00a00.10) and all\u2010cause mortality (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.31 [0.89\u20131.93], p\u00a0=\u00a00.18). The increased risk at low uric acid levels was confined to diabetic recipients. Uric acid was not associated with death\u2010censored graft loss. In conclusion, uric acid has a J\u2010shaped association with cardiovascular and all\u2010cause mortality in kidney transplant recipients.<\/jats:p>","DOI":"10.1111\/ctr.12290","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T07:33:08Z","timestamp":1387870388000},"page":"134-140","source":"Crossref","is-referenced-by-count":20,"title":["Uric acid has a <scp>J<\/scp>\u2010shaped association with cardiovascular and all\u2010cause mortality in kidney transplant recipients"],"prefix":"10.1111","volume":"28","author":[{"given":"Dag Olav","family":"Dahle","sequence":"first","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trond","family":"Jenssen","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital, Rikshospitalet Oslo Norway"},{"name":"Institute of Clinical Medicine University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hallvard","family":"Holdaas","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f8rn","family":"Leivestad","sequence":"additional","affiliation":[{"name":"Norwegian Renal Registry Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"V\u00e5rdal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Oslo University Hospital, Ullev\u00e5l Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Mj\u00f8en","sequence":"additional","affiliation":[{"name":"Department of Nephrology Oslo University Hospital, Ullev\u00e5l Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna V.","family":"Reis\u00e6ter","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Toft","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"359","article-title":"Uric acid and cardiovascular risk","volume":"2008","author":"Feig DI","year":"1811","journal-title":"N Engl J 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